Table 1.
ERG SNP rs2836371 genotype frequencies in Latino and non-Latino white Down syndrome (DS) ALL cases and DS non-leukemia controls from the International Study of Down Syndrome Acute Leukemia (IS-DSAL), measured by Taqman SNP genotyping
| rs2836371 genotype | Latinos | Non-Latino whites | ||||||
|---|---|---|---|---|---|---|---|---|
| Cases n = 103 (%) | Controls n = 96 (%) | P-value | OR (95% CI) | Cases n = 83 (%) | Controls n = 78 (%) | P-value | OR (95% CI) | |
| TTT | 26 (25.2) | 34 (35.4) | 0.016 | 1.44 (1.08–1.96) | 24 (28.9) | 26 (33.3) | 0.69 | 1.07 (0.77–1.49) |
| TTC | 33 (32.0) | 35 (36.5) | 36 (43.4) | 30 (38.5) | ||||
| TCC | 30 (29.1) | 22 (22.9) | 14 (16.9) | 15 (19.2) | ||||
| CCC | 14 (13.6) | 5 (5.2) | 9 (10.8) | 7 (9.0) | ||||
| Risk allele (C) frequency | 0.437 | 0.326 | 0.365 | 0.346 | ||||
| CCC vs. TTT* | 0.02 | 3.66 (1.17–11.47) | 0.57 | 1.39 (0.45–4.32) | ||||
P values and odds ratios (OR) are calculated using logistic regression tests, assuming the additive model unless specified
*P values and ORs calculated using chi-square tests