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. 2019 Sep 25;103(6):1096–1108.e4. doi: 10.1016/j.neuron.2019.06.027

Figure 5.

Figure 5

Bcl6 Binding to Significantly Downregulated Wnt-Related Genes Induces Chromatin Remodeling and Sirt1 Recruitment

(A) ChIP-qPCR of histone acetylation marks on Bcl6 binding sites of significantly downregulated Wnt-related genes in E12.5 wild-type and Bcl6−/− telencephalon using control (rabbit immunoglobulin G [IgG]) and H1.4K26ac and H4K16ac antibodies. Data are presented as mean + SEM of input enrichment (n = 6). ∗p < 0.05 and ∗∗p < 0.01 using Student’s t test.

(B) ChIP-qPCR on validated Bcl6 binding sites of significantly downregulated Wnt-related genes in E12.5 wild-type and Bcl6−/− telencephalon using a Sirt1 antibody. Data are presented as mean + SEM of input enrichment (n = 6). ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 using Student’s t test.

See also Figure S6.