FIGURE 7.

Splice-altering SNPs at the wobble position are selected against. The evolutionary conservation of exonic SNPs at wobble positions are compared between the delta psi groups that lead to increased exon exclusion, increased exon inclusion, or the control group that do not change exon inclusion levels. The relative representation of “Mutation-Not-Important” (red bars), “Mutation-Not-Observed” (blue bars), or “SNPs-With-Covariance” (green bars) are shown for (A) nonjunction exonic positions and (B) junction exonic positions.