S J Tavernier
S J Tavernier
1Primary Immune Deficiency Research Lab, Department of Internal Medicine and Pediatrics, Centre for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium
2VIB Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, Ghent, Belgium
3Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
1,2,3,#,
V Athanasopoulos
V Athanasopoulos
4Department of Immunology and Infectious Disease and Center for Personalised Immunology (NHMRC Centre for Research Excellence), John Curtin School of Medical Research, Australian National University, Canberra, Australia
5Centre for Personalised Immunology (CACPI), Shanghai Renji Hospital, Shanghai Jiao Tong University, Shanghai, China
4,5,#,
P Verloo
P Verloo
6Department of Internal Medicine and Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium
6,#,
G Behrens
G Behrens
7Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany
8Research Unit Molecular Immune Regulation, Helmholtz Zentrum München, Munich, Germany
7,8,
J Staal
J Staal
2VIB Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, Ghent, Belgium
3Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
2,3,
D J Bogaert
D J Bogaert
1Primary Immune Deficiency Research Lab, Department of Internal Medicine and Pediatrics, Centre for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium
9Department of Internal Medicine and Pediatrics, Division of Pediatric Immunology and Pulmonology, Ghent University Hospital, Ghent, Belgium
1,9,
L Naesens
L Naesens
1Primary Immune Deficiency Research Lab, Department of Internal Medicine and Pediatrics, Centre for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium
10Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium
1,10,
M De Bruyne
M De Bruyne
1Primary Immune Deficiency Research Lab, Department of Internal Medicine and Pediatrics, Centre for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium
11Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
1,11,
S Van Gassen
S Van Gassen
12VIB Center for Inflammation Research, Unit of Data Mining and Modeling for Biomedicine, Ghent, Belgium
13Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Gent, Belgium
12,13,
E Parthoens
E Parthoens
14VIB Bioimaging Core, VIB Center for Inflammation Research, Ghent, Belgium
14,
J Ellyard
J Ellyard
4Department of Immunology and Infectious Disease and Center for Personalised Immunology (NHMRC Centre for Research Excellence), John Curtin School of Medical Research, Australian National University, Canberra, Australia
4,
J Cappello
J Cappello
4Department of Immunology and Infectious Disease and Center for Personalised Immunology (NHMRC Centre for Research Excellence), John Curtin School of Medical Research, Australian National University, Canberra, Australia
4,
L X Morris
L X Morris
15The Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, Australia
15,
H Van Gorp
H Van Gorp
10Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium
16VIB Center for Inflammation Research, Ghent, Belgium
10,16,
G Van Isterdael
G Van Isterdael
3Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
17VIB Flow Core, VIB Center for Inflammation Research, Ghent, Belgium
3,17,
Y Saeys
Y Saeys
12VIB Center for Inflammation Research, Unit of Data Mining and Modeling for Biomedicine, Ghent, Belgium
13Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Gent, Belgium
12,13,
M Lamkanfi
M Lamkanfi
10Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium
16VIB Center for Inflammation Research, Ghent, Belgium
10,16,
P Schelstraete
P Schelstraete
9Department of Internal Medicine and Pediatrics, Division of Pediatric Immunology and Pulmonology, Ghent University Hospital, Ghent, Belgium
9,
J Dehoorne
J Dehoorne
18Department of Internal Medicine and Pediatrics, Division of Pediatric Rheumatology, Ghent University Hospital, Ghent, Belgium
18,
V Bordon
V Bordon
9Department of Internal Medicine and Pediatrics, Division of Pediatric Immunology and Pulmonology, Ghent University Hospital, Ghent, Belgium
9,
R Van Coster
R Van Coster
6Department of Internal Medicine and Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium
6,
B N Lambrecht
B N Lambrecht
19Department of Internal Medicine and Pediatrics, Division of Pulmonology, Ghent University Hospital, Ghent, Belgium
20VIB Center for Inflammation Research, Unit for Immunoregulation and Mucosal Immunology, Ghent, Belgium
21Department of Pulmonary Medicine, ErasmusMC, Rotterdam, The Netherlands
19,20,21,
B Menten
B Menten
11Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
11,
R Beyaert
R Beyaert
2VIB Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, Ghent, Belgium
3Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
2,3,
C G Vinuesa
C G Vinuesa
4Department of Immunology and Infectious Disease and Center for Personalised Immunology (NHMRC Centre for Research Excellence), John Curtin School of Medical Research, Australian National University, Canberra, Australia
5Centre for Personalised Immunology (CACPI), Shanghai Renji Hospital, Shanghai Jiao Tong University, Shanghai, China
4,5,
V Heissmeyer
V Heissmeyer
7Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany
8Research Unit Molecular Immune Regulation, Helmholtz Zentrum München, Munich, Germany
7,8,
M Dullaers
M Dullaers
1Primary Immune Deficiency Research Lab, Department of Internal Medicine and Pediatrics, Centre for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium
22Ablynx, a Sanofi Company, Zwijnaarde, Belgium
1,22,
F Haerynck
F Haerynck
1Primary Immune Deficiency Research Lab, Department of Internal Medicine and Pediatrics, Centre for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium
9Department of Internal Medicine and Pediatrics, Division of Pediatric Immunology and Pulmonology, Ghent University Hospital, Ghent, Belgium
1,9,✉
1Primary Immune Deficiency Research Lab, Department of Internal Medicine and Pediatrics, Centre for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium
2VIB Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, Ghent, Belgium
3Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
4Department of Immunology and Infectious Disease and Center for Personalised Immunology (NHMRC Centre for Research Excellence), John Curtin School of Medical Research, Australian National University, Canberra, Australia
5Centre for Personalised Immunology (CACPI), Shanghai Renji Hospital, Shanghai Jiao Tong University, Shanghai, China
6Department of Internal Medicine and Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium
7Institute for Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany
8Research Unit Molecular Immune Regulation, Helmholtz Zentrum München, Munich, Germany
9Department of Internal Medicine and Pediatrics, Division of Pediatric Immunology and Pulmonology, Ghent University Hospital, Ghent, Belgium
10Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium
11Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
12VIB Center for Inflammation Research, Unit of Data Mining and Modeling for Biomedicine, Ghent, Belgium
13Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Gent, Belgium
14VIB Bioimaging Core, VIB Center for Inflammation Research, Ghent, Belgium
15The Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, Australia
16VIB Center for Inflammation Research, Ghent, Belgium
17VIB Flow Core, VIB Center for Inflammation Research, Ghent, Belgium
18Department of Internal Medicine and Pediatrics, Division of Pediatric Rheumatology, Ghent University Hospital, Ghent, Belgium
19Department of Internal Medicine and Pediatrics, Division of Pulmonology, Ghent University Hospital, Ghent, Belgium
20VIB Center for Inflammation Research, Unit for Immunoregulation and Mucosal Immunology, Ghent, Belgium
21Department of Pulmonary Medicine, ErasmusMC, Rotterdam, The Netherlands
22Ablynx, a Sanofi Company, Zwijnaarde, Belgium
Subject terms: Disease genetics, Inflammation, RNA decay, Primary immunodeficiency disorders
© The Author(s) 2019
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
