Table. Summary of Case-Control Collections in a Study of the Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.
| Sample Collectiona | rs59892895*C Present, % | Sample Size, No. | ||
|---|---|---|---|---|
| Individuals With Primary Open-Angle Glaucoma | Control Individuals Without Primary Open-Angle Glaucoma | Individuals With Primary Open-Angle Glaucoma | Control Individuals Without Primary Open-Angle Glaucoma | |
| GWAS Discovery | ||||
| Ghana | 26.9 | 23.3 | 833 | 896 |
| Nigeria | 30.4 | 22.6 | 554 | 348 |
| South Africa | 31.1 | 22.9 | 228 | 269 |
| United States | 26.1 | 21.7 | 705 | 608 |
| Total | 2320 | 2121 | ||
| First Validation | ||||
| Women’s Health Initiative | 23.1 | 20.8 | 1720 | 6067 |
| Kaiser Permanente GERA | 23.3 | 18.4 | 300 | 2700 |
| ADAGES | 24.3 | 21.4 | 1890 | 2205 |
| South Africa | 13.0 | 14.4 | 297 | 147 |
| Tanzania | 30.1 | 28.3 | 366 | 329 |
| United States | 23.6 | 22.6 | 450 | 1350 |
| South London | 26.6 | 21.6 | 378 | 217 |
| Total | 5401 | 13 015 | ||
| Second Validation | ||||
| Cameroon | 31.3 | 29.0 | 56 | 57 |
| Nigeria | 28.6 | 26.2 | 231 | 61 |
| Nigeria (Kaduna) | 29.2 | 30.2 | 99 | 88 |
| Nigeria (African Glaucoma Genetics Project) | 32.6 | 31.0 | 131 | 71 |
| Saudi Arabia | 5.5 | 3.1 | 276 | 655 |
| Brazil | 8.8 | 4.5 | 399 | 460 |
| The Democratic Republic of the Congo | 37.7 | 33.9 | 124 | 120 |
| Morocco | 6.8 | 3.5 | 37 | 130 |
| Peru | 2.0 | 1.2 | 51 | 128 |
| Mali | 27.3 | 23.4 | 132 | 132 |
| Total | 1536 | 1902 | ||
| All validation | 6937 | 14 917 | ||
| Total samples | 9257 | 17 038 | ||
Abbreviations: ADAGES, African Descent and Glaucoma Evaluation Study; GERA, Genetic Epidemiology Research on Adult Health and Aging; GWAS, genome-wide association study.
a
The study site (country) or name of the study that the sample collection was taken from. More information on the sample collections can be found in the eAppendix in the Supplement.