Transcriptome signature of cellular senescence

Nucleic Acids Research (2019) 47: 7294–7305, https://doi.org/10.1093/nar/gkz555

The authors inadvertently omitted an important article (48) from the Demaria laboratory that should have been included in the Introduction:

Progress to identify senescent cells in order to exploit them therapeutically has been hampered by a lack of robust and universal measurable traits. Thus far, senescence has been studied in a range of cell types induced by diverse triggers such as replicative exhaustion, DNA damage, oxidation and other stress conditions like signaling through oncoproteins. Due to this heterogeneity, finding broad biomarkers of senescence has been challenging (16,48) and senescent cells are currently found through the combined detection of multiple biochemical markers such as p16, p53, p21 and SA-βGal, despite the fact that they are not exclusively nor consistently induced in senescence (17–20).