Animals were treated with TXT-NPs (12 mg/kg TXT dose equivalent NPs) to
determine the effect of first dosing. The subsequent dosing was administered
when tumor began to grow. Arrows indicate dosing schedule. Changes in
a) bioluminance signal in TXT-NPs treated vs. saline control
groups, p=0.008; b) body weight in treated vs. saline group, p=NS;
and c) survival of treated vs. saline control, p=0.04. Data are
expressed as the mean ± s.e.m., n= 3 to 4. Median survival for saline
group = 9.5 wks vs. 20 wks for treated group. X-axis abbreviation: D is for
days, whereas other time points are in weeks.