Table 1:
Cytotoxicity of TXT Soln and TXT-NPs in different prostate cancer cell lines
| Cell Line | End Point | Treatment | IC50 (ng/mL) | IC75 (ng/mL) | IC90 (ng/mL) |
|---|---|---|---|---|---|
| PC3 | 3 day | TXT-Soln | 2.5±0.05 | 4±0.03 | 6±0.2 |
| TXT-NPs | 2.6±0.04 | 5±0.1 | 14±0.3 | ||
| 5 day | TXT Soln | 1.6±0.01 | 2.5±0.02 | 5±0.07 | |
| TXT-NPs | 2±0.03 | 4±0.08 | 15±0.7 | ||
| 7 day | TXT-Soln | 1.6±0.01 | 2.5±0.01 | 4±0.08 | |
| TXT-NPs | 2±0.01 | 3.4±0.02 | 7±0.2 | ||
| DU145 | 5 day | TXT-Soln | 1.5±0.04 | 2±0.03 | 2±0.02 |
| TXT-NPs | 1.6±0.03 | 2.2±0.03 | 3±0.04 | ||
| LNCaP | 5 day | TXT-Soln | 8.3±0.3 | 22±1 | 60±2 |
| TXT-NPs | 20±0.5 | 76±3 | 208±6 | ||
| C42 | 5 day | TXT-Soln | 6±0.2 | 13±1 | 34±5 |
| TXT-NPs | 12±0.4 | 47±3 | 149±9 |
Cell seeding density/well/0.1mL in 96-well plate: For 3- and 5-d treatment in PC3 cells – 3,000 cells; for 7-d treatment – 1,500 cells/well. For DU145 cells – 3,000 cells. LNCaP and C42 cells – 10,000 cells. Data represented as mean ± s.e.m. (n=6).