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. 1999 Jul 2;8(1):44–59. doi: 10.1002/(SICI)1097-0193(1999)8:1<44::AID-HBM4>3.0.CO;2-#

Functional magnetic resonance imaging of neural activity related to orthographic, phonological, and lexico‐semantic judgments of visually presented characters and words

Norio Fujimaki 1,2,✉, S Miyauchi 2, B Pütz 3,6, Y Sasaki 2,7, R Takino 4, K Sakai and 5, T Tamada 3
PMCID: PMC6873327  PMID: 10432181

Abstract

Functional magnetic resonance imaging was used to investigate neural activity during the judgment of visual stimuli in two groups of experiments using seven and five normal subjects. The subjects were given tasks designed differentially to involve orthographic (more generally, visual form), phonological, and lexico‐semantic processes. These tasks included the judgments of whether a line was horizontal, whether a pseudocharacter or pseudocharacter string included a horizontal line, whether a Japanese katakana (phonogram) character or character string included a certain vowel, or whether a character string was meaningful (noun or verb) or meaningless. Neural activity related to the visual form process was commonly observed during judgments of both single real‐characters and single pseudocharacters in lateral extrastriate visual cortex, the posterior ventral or medial occipito‐temporal area, and the posterior inferior temporal area of both hemispheres. In contrast, left‐lateralized activation was observed in the latter two areas during judgments of real‐ and pseudo‐character strings. These results show that there is no katakana “word form center” whose activity is specific to real words. Activation related to the phonological process was observed, in Broca's area, the insula, the supramarginal gyrus, and the posterior superior temporal area, with greater activation in the left hemisphere. These activation foci for visual form and phonological processes of katakana also were reported for the English alphabet in previous studies. The present activation showed no additional areas for contrasts of noun judgment with other conditions and was similar between noun and verb judgment tasks, suggesting two possibilities: no strong semantic activation was produced, or the semantic process shared activation foci with the phonological process. Hum. Brain Mapping 8:44–59, 1999. © 1999 Wiley‐Liss, Inc.

Keywords: language, lateralization, pseudocharacter, vowel, noun, verb, Japanese, katakana

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REFERENCES

  1. Allison T, McCarthy G, Nobre A, Puce A, Belger A. 1994. Human extrastriate visual cortex and the perception of faces, words, numbers, and colors. Cereb Cortex 5:544–554. [DOI] [PubMed] [Google Scholar]
  2. Bandettini PA, Jesmanowicz A, Wong EC, Hyde JS. 1993. Processing strategies for time‐course data sets in functional MRI of the human brain. Magn Reson Med 30:161–173. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=93375843&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  3. Bookheimer SY, Zeffiro TA, Blaxton T, Gaillard W, Theodore W. 1995. Regional cerebral blood flow during object naming and word reading. Hum Brain Mapp 3:93–106. [Google Scholar]
  4. Corbetta M, Miezin FM, Shulman GL, Petersen SE. 1993. A PET study of visuospatial attention. J Neurosci 13:1202–1226. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=93179925&form=6&db=m&Dopt=r [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Damasio H, Grabowski TJ, Tranel D, Hichwa RD, Damasio AR. 1996. A neural basis for lexical retrieval. Nature 380:499–505. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=96195054&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  6. Demb JB, Desmond JE, Wagner AD, Vaidya CJ, Glover GH, Gabrieli JDE. 1995. Semantic encoding and retrieval in the left inferior prefrontal cortex: a functional MRI study of task difficulty and process specificity. J Neurosci 15:5870–5878. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=95395573&form=6&db=m&Dopt=r [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Démonet JF, Chollet F, Ramsay S, Cardebat D, Nespoulous JL, Wise R, Rascol A, Frackowiak R. 1992. The anatomy of phonological and semantic processing in normal subjects. Brain 115:1753–1768. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=93136984&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  8. Démonet JF, Price C, Wise R, Frackowiak RSJ. 1994. Differential activation of right and left posterior sylvian regions by semantic and phonological tasks: a positron‐emission tomography study in normal human subjects. Neurosci Letts 182:25–28. [DOI] [PubMed] [Google Scholar]
  9. Démonet JF, Fiez JA, Paulesu E, Petersen SE, Zatorre RJ. 1996. PET studies of phonological processing: a critical reply to Poeppel. Brain Lang 55:352–379. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=0&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  10. Dronkers NF. 1996. A new brain region for coordinating speech articulation. Nature 384:159–161. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=97064170&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  11. Frith CD, Friston KJ, Liddle PF, Frackowiak RSJ. 1991. A PET study of word finding. Neuropsychologia 29:1137–1148. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=92168336&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  12. Frith CD, Kapur N, Friston KJ, Liddle PF, Frackowiak RSJ. 1995. Regional cerebral activity associated with the incidental processing of pseudo‐words. Hum Brain Mapp 3:153–160. [Google Scholar]
  13. Fujimaki N, Hirata Y, Kuriki S, Nakajima H. 1995. Event‐related magnetic fields at latencies of over 400 ms in silent reading of Japanese katakana meaningless words. Neurosci Res 23:419–422. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=96167738&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  14. Herbster AN, Mintun MA, Nebes RD, Becker JT. 1997. Regional cerebral blood flow during word and nonword reading. Hum Brain Mapp 5:84–92. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=99194077&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  15. Howard D, Patterson K, Wise R, Brown WD, Friston K, Weiller C, Frackowiak R. 1992. The cortical localization of the lexicons. Brain 115:1769–1782. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=93136985&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  16. Imada T, Kawakatsu M, Kotani M. 1996. Analysis of magnetic signals related to reading Japanese characters (hiragana) In: Hashimoto I, Okada YC, Ogawa S, (eds): Visualization of Information Processing in the Human Brain: Recent Advances in MEG and Functional MRI. (EEG Suppl. 47) Amsterdam: Elsevier Science; p 199–208. [PubMed] [Google Scholar]
  17. Iwata M. 1984. Kanji versus Kana: neuropsychological correlates of the Japanese writing system. Trends Neurosci 7:290–293. [Google Scholar]
  18. Kawakatsu M, Kotani M, 1996. Magnetoencephalography in the understanding of kana word (in Japanese). Trans IEE Japan 116–C:669–675. [Google Scholar]
  19. Koyama S, Kakigi R, Hoshiyama M, Kitamura Y. 1998. Reading of Japanese kanji (morphograms) and kana (syllabograms): a magnetoencephalographic study. Neuropsychologia 36:83–98. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=98192061&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  20. Kuriki S, Hirata Y, Fujimaki N, Kobayashi T. 1996. Magnetoencephalographic study on the cerebral neural activities related to the processing of visually presented characters. Cogn Brain Res 4:185–199. [DOI] [PubMed] [Google Scholar]
  21. Kuriki S, Takeuchi F, Hirata Y. 1998. Neural processing of words in the human extrastriate visual cortex. Cogn Brain Res 6:193–203. [DOI] [PubMed] [Google Scholar]
  22. Law I, Kannao I, Fujita H, Lassen NA, Miura S, Uemura K. 1991. Left supramarginal/angular gyri activation during reading of syllabograms in the Japanese language. J Neurolinguistics 6:243–251. [Google Scholar]
  23. Mayeux R, Kandel ER. 1991. Disorders of language: the aphasias In: Kandel ER, Schwartz JH, Jessell TM, (eds): Principles of Neural Science, 3rd ed. New York: Elsevier, pp 840–851 [Google Scholar]
  24. Mummery CJ, Patterson K, Hodges JR, Wise RJS. 1996. Generating ‘tiger’ as an animal name or a word beginning with T: differences in brain activation. Proc R Soc Lond B263:989–995. [DOI] [PubMed] [Google Scholar]
  25. Müri RM, Iba‐Zizen MT, Derosier C, Cabanis EA, Pierrot‐Deseilligny C. 1996. Location of the human posterior eye field with functional magnetic resonance imaging. J Neurol Neurosurg, Psychiatr 60:445–448. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Nobre AC, Allison T, McCarthy G. 1994. Word recognition in the human inferior temporal lobe. Nature 372:260–263. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=95059450&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  27. Nobre AC, Sebestyen GN, Gitelman DR, Mesulam MM, Frackowiak RSJ, Frith CD. 1997. Functional localization of the system for visuospatial attention using positron emission tomography. Brain 120:515–533. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=97271111&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  28. Oldfield RC. 1971. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97–113. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=72164093&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  29. Paulesu E, Frith CD, Frackowiak RSJ. 1993. The neural correlates of the verbal component of working memory. Nature 362:342–345. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=93205118&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  30. Paus T. 1996. Location and function of the human frontal eye‐field: a selective review. Neuropsychologia 34:475–483. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=96347164&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  31. Petit L, Clark VP, Ingeholm J, Haxby JV. 1997. Dissociation of saccade‐related and pursuit‐related activation in human frontal eye fields as revealed by fMRI. J Neurophysiol 77:3386–3390. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=97355802&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  32. Petersen SE, Fox PT, Posner MI, Mintun M, Raichle ME. 1989. Positron emission tomographic studies of the processing of single‐words. J Cogn Neurosci 1:153–170. [DOI] [PubMed] [Google Scholar]
  33. Petersen SE, Fox PT, Snyder AZ, Raichle ME. 1990. Activation of extrastriate and frontal cortical areas by visual words and word‐like stimuli. Science 249:1041–1044. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=90371300&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  34. Poeppel D. 1996. A critical review of PET studies of phonological processing. Brain Lang 55:317–351. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=97123286&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  35. Posner MI, Petersen SE, Fox PT, Raichle ME. 1988. Localization of cognitive operations in the human brain. Science 240:1627–1631. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=88248691&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  36. Price CJ, Wise RJS, Watson JDG, Patterson K, Howard D, Frackowiak RSJ. 1994. Brain activity during reading: the effects of exposure duration and task. Brain 117:1255–1269. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=95120487&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  37. Pugh KR, Shaywitz BA, Shaywitz SE, Constable RT, Skudlarski P, Fulbright RK, Bronen RA, Shankweiler DP, Katz L, Fletcher JM, Gore JC. 1996. Cerebral organization of component processes in reading. Brain 119:1221–1238. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=96408240&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  38. Raichle ME, Fiez JA, Videen TO, MacLeod AMK, Pardo JV, Fox PT, Petersen SE. 1994. Practice‐related changes in human brain functional anatomy during nonmotor learning. Cereb Cortex 4:8–26. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=94235980&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  39. Sakurai Y, Momose T, Iwata M, Watanabe T, Ishikawa T, Takeda K, Kanazawa I. 1992. Kanji word reading process analysed by positron emission tomography. NeuroReport 3:445–448. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=92338349&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  40. Sakurai Y, Momose T, Iwata M, Watanabe T, Ishikawa T, Kanazawa I. 1993. Semantic process in kana word reading: activation studies with positron emission tomography. NeuroReport 4:327–330. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=93237498&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  41. Sasaki Y, Miyauchi S, Fujimaki N, Takino R, Pütz B. 1997. Brain activities during visuospatial attention revealed by functional magnetic resonance imaging (fMRI) (in Japanese). Jap J Physiological Psychol Psychophysiol 15:67–75. [Google Scholar]
  42. Sergent J, Zuck E, Lévesque M, MacDonald B. 1992. Positron emission tomography study of letter and object processing: empirical findings and methodological considerations. Cereb Cortex 2:68–80. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=92338557&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  43. Sugishita M, Otomo K, Kabe S, Yunoki K. 1992. A critical appraisal of neuropsychological correlates of Japanese ideogram (kanji) and phonogram (kana) reading. Brain 115:1563–1585. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=93045456&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  44. Vandenberghe R, Price C, Wise R, Josephs O, Frackowiak RSJ. 1996. Functional anatomy of a common semantic system for words and pictures. Nature 383:254–256. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=96399129&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  45. Wise R, Chollet F, Hadar U, Friston K, Hoffner E, Frackowiak R. 1991. Distribution of cortical neural networks involved in word comprehension and word retrieval. Brain 114:1803–1817. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=91356253&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  46. Yamada N, Sakuma T, Nishino T, Imakita S, Yamada Y, Takamiya M. 1995. Role of susceptibility effect of blood in functional MRI at 1.5T (in Japanese). Jap J Magn Res Med 15:43–49. [Google Scholar]
  47. Zatorre RJ, Evans AC, Meyer E, Gjedde A. 1992. Lateralization of phonetic and pitch discrimination in speech processing. Science 256:846–849. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=92271209&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]
  48. Zatorre RJ, Meyer E, Gjedde A, Evans AC. 1996. PET studies of phonetic processing of speech: review, replication, and reanalysis. Cereb Cortex 6:21–30. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=96324282&form=6&db=m&Dopt=r [DOI] [PubMed] [Google Scholar]

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