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. 1998 Dec 7;6(5-6):399–402. doi: 10.1002/(SICI)1097-0193(1998)6:5/6<399::AID-HBM13>3.0.CO;2-H

Transcranial magnetic stimulation during PET: Reaching and verifying the target site

Tomáš Paus 1,✉, Mark Wolforth 2
PMCID: PMC6873354  PMID: 9788080

Abstract

Transcranial magnetic stimulation (TMS) during positron emission tomography (PET) is a novel technique for in vivo measurements of connectivity and excitability of the human cerebral cortex. Here we describe tools that allow investigators to position the stimulating coil over a target region and to verify the actual position of the coil after the study. The former is achieved by coregistering the head of the subject with an MR image of his/ her brain using frameless stereotaxy. The latter is accomplished by identifying the coil on a transmission scan and coregistering it, e.g., with a model of the electrical field induced in the brain. Hum. Brain Mapping 6:399–402, 1998. © 1998 Wiley‐Liss, Inc.

Keywords: TMS, PET, connectivity, cerebral cortex, registration, frameless stereotaxy

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References

  1. Brasil‐Neto JP, Cohen LG, Panizza M (1992): Optimal focal transcranial magnetic activation of the human motor cortex: Effects of coil orientation, shape of the induced current pulse, and stimulus intensity. Acta Neurol Scand 92: 383–386. [PubMed] [Google Scholar]
  2. Cohen LG, Roth BJ, Nilsson J, et al. (1990): Effects of coil design on delivery of focal magnetic stimulation. Technical considerations. EEG Clin Neurophysiol 75: 350–357. [DOI] [PubMed] [Google Scholar]
  3. Cracco RQ, Amassian VE, Maccabee PJ, et al. (1993): Insights into cerebral function revealed by magnetic coil stimulation. Adv Neurol 63: 43–50. [PubMed] [Google Scholar]
  4. Ettinger GJ, Grimson WEL, Leventon ME, Kikinis R, Gugino V, Cote W, Karapelou M, Aglio L, Shenton M, Potts G, Alexander E (1996): Non‐invasive functional brain mapping using registered transcranial magnetic stimulation. In: IEEE Workshop on Mathematical Methods in Biomedical Image Analysis. San Francisco.
  5. Fox P, Ingham R, George MS, Mayberg H, Ingham J, Roby J, Martin C, Jerabek P (1997): Imaging human intra‐cerebral connectivity by PET during TMS. Neuroreport 8: 2787–2791. [DOI] [PubMed] [Google Scholar]
  6. Hallett M, Cohen LG (1989): A new method for stimulation of nerve and brain. JAMA 262: 538–541. [DOI] [PubMed] [Google Scholar]
  7. Hotson J, Braun D, Herzberg W, Boman D (1994): Transcranial magnetic stimulation of extrastriate cortex degrades human motion direction discrimination. Vision Res 34: 2115–2123. [DOI] [PubMed] [Google Scholar]
  8. Jennum P, Friberg L, Fuglsang‐Frederiksen A, Dam M (1994): Speech localization using repetitive transcranial magnetic stimulation. Neurology 44: 269–273. [DOI] [PubMed] [Google Scholar]
  9. Miller MB, Fendrich R, Eliassen JC, Demirel S, Gazzaniga MS (1996): Transcranial magnetic stimulation: Delays in visual suppression due to luminance changes. Neuroreport 7: 1740–1744. [PubMed] [Google Scholar]
  10. Mills KR, Boniface SJ, Schubert M (1992): Magnetic brain stimulation with a double coil: The importance of coil orientation. EEG Clin Neurophysiol 85: 17–21. [DOI] [PubMed] [Google Scholar]
  11. Müri RM, Rösler KM, Hess CW (1994): Influence of transcranial magnetic stimulation on the execution of memorised sequences of saccades in man. Exp Brain Res 101: 521–524. [DOI] [PubMed] [Google Scholar]
  12. Murray NMF (1992): The clinical usefulness of magnetic cortical stimulation. EEG Clin Neurophysiol 85: 81–85. [DOI] [PubMed] [Google Scholar]
  13. Pascual‐Leone A, Gates JR, Dhuna A (1991): Induction of speech arrest and counting errors with rapid‐rate transcranial magnetic stimulation. Neurology 41: 697–702. [DOI] [PubMed] [Google Scholar]
  14. Pascual‐Leone A, Gomez‐Tortosa E, Grafman J, Alway D, Nichelli P, Hallett M (1994): Induction of visual extinction by rapid‐rate transcranial magnetic stimulation of parietal lobe. Neurology 44: 494–498. [DOI] [PubMed] [Google Scholar]
  15. Paus T, Jech R, Thompson CJ, Comeau R, Peters T, Evans A (1997): Transcranial magnetic stimulation during positron emission tomography: A new method for studying connectivity of the human cerebral cortex. J Neurosci 17: 3178–3184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Paus T, Jech R, Thompson CJ, Comeau R, Peters T, Evans A (1998): Dose‐dependent reduction in cerebral blood‐flow during rapidrate transcranial magnetic stimulation of the human sensorimotor cortex. J Neurophysiol 79: 1102–1107. [DOI] [PubMed] [Google Scholar]
  17. Peters T, Davey B, Munger P, Comeau R, Evans A, Olivier A (1996): Three‐dimensional multimodal image‐guidance for neurosurgery. IEEE Trans Med Imaging 15: 121–128. [DOI] [PubMed] [Google Scholar]
  18. Priori A, Berardelli A, Inghilleri M, et al. (1994): Motor cortical inhibition and the dopaminergic system. Pharmacological changes in the silent period after transcranial brain stimulation in normal subjects, patients with Parkinson's disease and drug‐induced parkinsonism. Brain 117: 317–323. [DOI] [PubMed] [Google Scholar]
  19. Roth BJ, Saypol JM, Hallett M, Cohen LG (1991): A theoretical calculation of the electric field induced in the cortex during magnetic stimulation. EEG Clin Neurophysiol 81: 47–56. [DOI] [PubMed] [Google Scholar]
  20. Seyal M, Siddiqui I, Hundal NS (1997): Suppression of spatial localization of a cutaneous stimulus following transcranial magnetic pulse stimulation of the sensorimotor cortex. EEG Clin Neurophysiol 105: 24028. [DOI] [PubMed] [Google Scholar]
  21. Singh KD, Hamdy S, Aziz Q, Thompson DG (1997): Topographic mapping of trans‐cranial magnetic stimulation data on surface rendered MR images of the brain. EEG Clin Neurophysiol 105: 345–351. [DOI] [PubMed] [Google Scholar]
  22. Talairach J, Tournoux P (1988): Co‐Planar Stereotactic Atlas of the Human Brain: Three‐Dimensional Proportional System: An Approach to Cerebral Imaging. Stuttgart and New York: Georg Thieme Verlag. [Google Scholar]
  23. Zinreich SJ, Tebo S, Long DM, Brem H, Mattox D, Loury ME, Van der Volk C, Kotch W, Kennedy DW, Bryan RN (1993): Frameless stereotactic integration of CT imaging data. Radiology 188: 735–742. [DOI] [PubMed] [Google Scholar]

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