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. 2010 Jul 16;19(3):125–141. doi: 10.1002/mpr.317

The Netherlands Mental Health Survey and Incidence Study‐2 (NEMESIS‐2): design and methods

Ron de Graaf 1,✉, Margreet ten Have 1, Saskia van Dorsselaer 1
PMCID: PMC6878518  PMID: 20641046

Abstract

The psychiatric epidemiological population study NEMESIS‐2 (Netherlands Mental Health Survey and Incidence Study‐2) replicates and expands the first Netherlands Mental Health Survey and Incidence Study (NEMESIS‐1) conducted from 1996 to 1999. The main objectives of the new study are to provide up‐to‐date figures on the prevalence, incidence, course and consequences of mental disorders, and to study trends in mental disorders and service use, with the use of a new sample. New topics not included in NEMESIS‐1 were added, e.g. impulse‐control disorders, and genetic correlates of mental disorders through gathering DNA from saliva samples. This paper gives an overview of the design of NEMESIS‐2, especially of its recently completed first wave. NEMESIS‐2 is a prospective study among Dutch‐speaking subjects aged 18–64 years from the general Dutch population. Its baseline wave included 6646 subjects. Three waves are planned with three year‐intervals between the waves. A multistage, stratified random sampling procedure was applied. The baseline wave of NEMESIS‐2 was performed between November 2007 and July 2009. Face‐to‐face interviews were administered with the Composite International Diagnostic Interview (CIDI) 3.0. The response rate was 65.1%, and 76.4% of the respondents donated saliva. The sample was reasonably nationally representative, but younger subjects were somewhat underrepresented. In conclusion, we were able to build a comprehensive dataset of good quality, permitting several topics to be studied in the future. Copyright © 2010 John Wiley & Sons, Ltd.

Keywords: prospective general population study, mood disorder, anxiety disorder, substance use disorder, impulse‐control disorder

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Acknowledgements

The Netherlands Mental Health Survey and Incidence Study‐2 (NEMESIS‐2) is conducted by the Netherlands Institute of Mental Health and Addiction (Trimbos Institute) in Utrecht. Financial support has been received from the Ministry of Health, Welfare and Sport, with supplement support from the Netherlands Organization for Health Research and Development (ZonMw) and the Genetic Risk and Outcome of Psychosis (GROUP) Investigators. Further support has been received from the National Institute for Public Health and Environment (RIVM). We thank the staff of the World Mental Health Data Collection and Data Analysis Coordination Centres for assistance with instrumentation, and consultation on data analyses (Prof. Ronald Kessler, Nancy Sampson, Alison Hoffnagle, Nicholos Allis). We thank the external [Prof. Paul Schnabel (chair), Prof. Aartjan Beekman, Prof. Jozien Bensing, Prof. Wim van den Brink, Wim Brunenberg, Prof. Hans van Oers, Prof. J. (Hans) Ormel and Mady Samuels] and internal advisory committee (Margriet van Laar, Prof. Filip Smit and Jan Walburg) for their contribution to the study.

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