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. 2019 Nov 26;7:e8096. doi: 10.7717/peerj.8096

Table 1. Top five GO terms and significant pathways enriched by DEGs.

Expression change Category Term Count FDR
Up BP GO:0006955 ∼immune response 82 1.68E–27
GO:0006954 ∼inflammatory response 65 4.94E–18
GO:0060333 ∼interferon-gamma-mediated signaling pathway 25 1.81E–12
GO:0050776 ∼regulation of immune response 37 1.17E–11
GO:0051607 ∼defense response to virus 31 1.68 E–27
CC GO:0009897 ∼external side of plasma membrane 40 1.37 E–11
GO:0005886 ∼plasma membrane 267 4.06 E–11
GO:0009986 ∼cell surface 66 5.70 E–11
GO:0005887 ∼integral component of plasma membrane 118 2.64 E–09
GO:0005615 ∼extracellular space 107 6.10 E–07
MF GO:0004872 ∼receptor activity 32 5.21 E–06
GO:0005102 ∼receptor binding 42 9.04 E–06
GO:0042605 ∼peptide antigen binding 12 1.35 E–05
GO:0005201 ∼extracellular matrix structural constituent 14 6.51 E–03
GO:0005515 ∼protein binding 431 2.13 E–02
PATHWAY hsa04145:Phagosome 37 5.57 E–12
hsa05416:Viral myocarditis 23 3.25 E–11
hsa05330:Allograft rejection 19 5.75 E–11
hsa05332:Graft-versus-host disease 18 8.75 E–11
hsa05150:Staphylococcus aureus infection 22 1.07 E–10
Down BP GO:0055114 ∼oxidation–reduction process 56 1.02 E–09
GO:0006814∼sodium ion transport 16 5.11 E–05
GO:0007588 ∼excretion 11 2.49 E–04
GO:0055078 ∼sodium ion homeostasis 7 6.67 E–04
GO:0001657 ∼ureteric bud development 10 3.58 E–03
CC GO:0070062 ∼extracellular exosome 215 7.05 E–38
GO:0016324 ∼apical plasma membrane 44 9.64 E–15
GO:0016323 ∼basolateral plasma membrane 31 4.53 E–11
GO:0005759 ∼mitochondrial matrix 38 1.05E–08
GO:0005782 ∼peroxisomal matrix 11 0.001373
MF GO:0003824 ∼catalytic activity 23 1.23E–04
GO:0009055 ∼electron carrier activity 16 1.42E–04
GO:0050660 ∼flavin adenine dinucleotide binding 13 7.38E–04
GO:0016491 ∼oxidoreductase activity 22 1.50E–03
GO:0030170 ∼pyridoxal phosphate binding 12 1.64E–03
PATHWAY hsa01100:Metabolic pathways 111 3.54E–16
hsa01130:Biosynthesis of antibiotics 31 1.14E–06
hsa00280:Valine, leucine and isoleucine degradation 13 2.41E–04
hsa01200:Carbon metabolism 18 2.50E–03
hsa00071:Fatty acid degradation 11 5.18E–03