Fig. 4.

Assessment of cognitive performance by learning index for male (a, b) and female (c, d) WT and Sod1KO mice during the initial discrimination and reversal phase of learning. Figs. a and c represent the cumulative learning index and Figs b and d represent the independent learning index over the period of the study. Learning behavior during the initial discrimination phase was not statistically significant between WT and Sod1KO in male or female mice. Statistically significant changes were observed in the reversal phase of learning based on analysis of the independent learning index. Horizontal bars in Figs. a and c indicate the dark phase of the L:D cycle. *p < 0.05