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. 2019 Feb 5;59(3):437. doi: 10.1002/jcph.1383

Erratum

PMCID: PMC6885922  PMID: 30735259

Zeng Y, Singh S, Wang K, Ahrens RC. Effect of study design on sample size in studies intended to evaluate bioequivalence of inhaled short‐acting β‐agonist formulations. J Clin Pharmacol. 2018;58(4):457‐465.

Table 2 in the original article summarizing the within‐subject variance across previously published studies had calculation errors. These errors have been corrected and are presented below in the revised Table 2.

Table 2.

Estimate of Within‐Subject Variance From Previously Published Studies

Authors (Reference) Drug Studieda Within‐Subject Varianceb
Ahrens et al6 SABA 1.125
Prabhakaran et al9 LABA 0.187
Parameswaran et al10 SABA 0.115
Higham et al11 SABA 1.584
Inman et al12 SABA 0.583
Giannini et al13 SABA 1.988
Creticos et al14 SABA 0.552
Langley et al15 LABA 1.928
Allan et al16 LABA 0.718
a

SABA indicates short‐acting beta agonist (albuterol); LABA indicates long‐acting beta agonist (formoterol or salmeterol).

b

Obtained from data in publication, complete data set14; s/b ratio (where s is the within‐subject error and b is the dose‐response slope)6,10; treatment effect expressed as “doubling doses” relative to placebo9,11‐13,15 or within‐subject variance.16

The revisions in Table 2 will also result in a correction in the Discussion section of the article on page 463. The corrected sentence should read: “Within‐subject variance observed in prior work ranged from 0.115 to 1.988 (Table 2).6,9‐16


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