‘β‐Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial–mesenchymal transition’
by Adam Giangreco, Liwen Lu, Charles Vickers, Vitor Hugo Teixeira, Karen R Groot, Colin R Butler, Ekaterina V Ilieva, P Jeremy George, Andrew G Nicholson, Elizabeth K Sage, Fiona M Watt, and Sam M Janes, J Pathol 2012; 226: 575–587. DOI: https://doi.org/10.1002/path.3962
In the published version of Figure 1 of this paper, histology images from an area of normal epithelium were mislabelled as metaplasia. The corrected figure, shown below, depicts metaplastic epithelium (Figure 1A, 1C, 1E and 1G). The scale bar in Figure 1H was also found to be of the incorrect length and has also been corrected. These changes affect neither the analyses performed in Figure 1I‐K nor the overall interpretation of this Figure. The authors apologise for any confusion caused.
Figure 1.
β‐Catenin signalling is positively associated with human preinvasive lung cancer severity. (A–H) Representative images of adjacent serial sections from metaplastic (A, C, E, G) and severely dysplastic (B, D, F, H) human lung cancer biopsies stained with H&E (A, B) or antibodies directed against β‐catenin (C, D), Ki67 (E, F), and E‐cadherin (G, H). (I) Quantitation of the percentage of biopsy samples exhibiting membranous (white bars) or nuclear/cytoplasmic β‐catenin (black bars) in the tissue section per disease stage. (J, K) Ki67 incidence and basal E‐cadherin quantitation in samples exhibiting membranous or nuclear/cytoplasmic β‐catenin (white and black bars, respectively). Scale bars = 100 μm; *p < 0.005