Skip to main content
Wiley Open Access Collection logoLink to Wiley Open Access Collection
. 2016 Dec 19;12(2):194–195. doi: 10.1002/cmdc.201600619

Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors

Madeline E Kavanagh, Janine L Gray, Sophie H Gilbert, Anthony G Coyne, Kirsty J McLean, Holly J Davis, Andrew W Munro, Chris Abell
PMCID: PMC6886599  PMID: 28112499

The authors would like to make the following corrections to the original manuscript. The data and conclusions discussed in the text remain unchanged by this Corrigendum:

a) On page 1927, left column, paragraph 1, the sentences that read “Deprotection of the α‐amino group under anhydrous acidic conditions yielded the desired ligands 2, 3, and 5 as their hydrochloride salts, while compound 4 was retained as the N α‐acetyl protected ester. Both compounds 2 and 3, and the 1‐N‐methylated analogue 5, produced type II shifts of +4.0–4.5 nm in the Soret λ max of the CYP121 optical spectrum. In contrast, the N α‐acetylated analogue 3 did not produce a significant change in the Soret (Δλ max<1 nm)” should instead read:

“Deprotection of the α‐amino group under anhydrous acidic conditions yielded the desired ligands 2, 3, and 4 as their hydrochloride salts, while compound 5 was retained as the N α‐acetyl protected ester. Both compounds 2 and 3, and the 1‐N‐methylated analogue 4, produced type II shifts of +4.0–4.5 nm in the Soret λ max of the CYP121 optical spectrum. In contrast, the N α‐acetylated analogue 5 did not produce a significant change in the Soret (Δλ max<1 nm)”.

b) On page 1928, right column, paragraph 1, the sentence that reads “Thiol precursors that were not commercially available, such as those required for the synthesis of compounds 17, 23, 23, and 25 (Table 4)” should instead read:

“Thiol precursors that were not commercially available, such as those required for the synthesis of compounds 17, 22, 23, and 25 (Table 4)”.

c) On page 1925, Figure 1 is incorrect. The corrected version of Figure 1 should be the following: Inline graphic

d) On page 1930, Table 5, the correct structure for Compound 30 should be the following: Inline graphic


Articles from Chemmedchem are provided here courtesy of Wiley

RESOURCES