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. Author manuscript; available in PMC: 2019 Dec 3.
Published in final edited form as: Leukemia. 2019 May 16;33(12):2884–2897. doi: 10.1038/s41375-019-0478-9

Figure 5. Genes upregulated by S1P and correlated with SPHK1 mRNA are expressed in DLBCL tumour vasculature.

Figure 5

(A) GO analysis of genes upregulated by S1P in HUVEC revealed a significant enrichment of GO terms associated with angiogenesis. B) Genes upregulated (left panel), but not those downregulated (not shown) in S1P-treated HUVEC were enriched among genes positively correlated with SPHK1 expression in primary DLBCL. Genes downregulated (right panel), but not those upregulated (not shown) in S1P-treated HUVEC were enriched among genes negatively correlated with SPHK1 expression in primary DLBCL. (C) Representative examples of the expression of the S1P target genes, CXCL12, SELE, COL1A1 and MAP1B, in the tumour vasculature of DLBCL. Original magnifications x200.