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In vitro exposure of HUVEC to C5a demonstrated amelioration of the inflammatory response by IαI. a IαI reduced levels of IL-6, FGF-2 and GM-CSF that were increased by C5a. b IαI increased levels of MCP-1, PDGF, and IFN-γ that were reduced by C5a exposure. c IαI decreased activation of ERK and d IαI decreased activation of NFκB when dosed together with C5a. PBS=phosphate buffered saline vehicle
