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. Author manuscript; available in PMC: 2020 Jul 2.
Published in final edited form as: Circulation. 2019 Apr 15;140(1):55–66. doi: 10.1161/CIRCULATIONAHA.119.039751

Figure 2. Cardiomyocytes-specific KO of NEXN results in reduced cardiac function.

Figure 2.

(A-F) Representative echocardiographic M-mode images of NEXN mice: (A) P1 CTRL, %FS 40, LVIDd 0.84mm, LVIDs 0.50mm, heart rate (HR) 297; (B) P5 CTRL, %FS 46, LVIDd 1.42mm, LVIDs 0.76mm, HR 455; (C) P10 CTRL, %FS 49, LVIDd 1.96mm, LVIDs 1.03mm, HR 484; (D) P1 cKO, %FS 25, LVIDd 1.15mm, LVIDs 0.81mm, HR 410; (E) P5 cKO, %FS 9, LVIDd 3.40mm, LVIDs 3.08mm, HR 492; (F) P10 cKO, %FS 5, LVIDd 4.29mm, LVIDs 4.14mm, HR 422. (G-I) graphs representing echocardiographic measurements from CTRL and cKO mice (n = 6-7 mice per time point): (G) % FS, (H) LVIDd and (I) LVIDs. Echocardiographic parameters reported in Supplemental Table 3. (*) Statistically significant differences with P value < 0.05.