Table 2.

Cytotoxicity of compounds 5a‒5o against five cancer cell lines.

Compound	IC50 (μM)
	Hela	HepG2	H1299	HCT-116	MCF-7
5a	41.0 ± 4.5	43.0 ± 3.3	71.8 ± 5.7	83.9 ± 1.3	56.1 ± 0.7
5b	39.5 ± 2.2	36.8 ± 1.1	54.3 ± 1.0	65.8 ± 2.0	32.9 ± 1.9
5c	39.9 ± 0.9	36.8 ± 3.1	81.7 ± 5.5	33.5 ± 0.3	>100
5d	48.3 ± 4.3	33.2 ± 4.3	56.9 ± 1.0	56.6 ± 1.4	41.0 ± 0.4
5e	51.8 ± 1.9	23.6 ± 2.4	38.0 ± 1.8	44.7 ± 0.9	39.9 ± 1.7
5f	32.2 ± 0.7	29.6 ± 1.9	40.5 ± 2.1	30.6 ± 1.4	35.5 ± 0.9
5g	41.4 ± 2.9	37.6 ± 3.7	46.3 ± 2.2	38.8 ± 1.8	41.1 ± 1.2
5h	24.3 ± 2.8	18.1 ± 0.6	29.6 ± 0.7	32.6 ± 0.9	20.5 ± 0.8
5i	37.5 ± 1.5	32.9 ± 4.1	32.9 ± 0.8	53.7 ± 1.4	36.6 ± 0.8
5j	24.6 ± 1.0	31.1 ± 3.3	50.2 ± 2.8	41.8 ± 0.2	24.6 ± 1.7
5k	35.9 ± 2.1	54.4 ± 1.4	63.9 ± 2.2	>100	54.5 ± 4.3
5l	22.6 ± 1.8	49.9 ± 1.5	62.6 ± 2.2	46.3 ± 1.0	50.7 ± 4.1
5m	29.7 ± 2.1	30.6 ± 4.3	31.5 ± 1.1	42.1 ± 1.3	29.3 ± 1.8
5n	33.8 ± 5.6	58.9 ± 2.1	81.9 ± 4.6	50.6 ± 1.4	69.5 ± 2.5
5o	44.3 ± 4.3	41.9 ± 2.7	70.8 ± 7.2	54.7 ± 0.6	82.3 ± 5.4
Regosertib	0.01 ± 0	0.05 ± 0.01	0.14 ± 0.02	2.36 ± 0.21	0.83 ± 0.08