Figure 6.

Diet- and exercise-dependent induction of hepatic FGF21 production. (A) Fibroblast growth factor 21 (FGF21) mRNA expression was quantified by RT-qPCR in liver samples from the different intervention groups described in the legend to Figure 1. (B) FGF21 plasma protein concentration was determined. Values are median (line), upper and lower quartile (box) and extremes (whiskers). Statistics: Two-way-ANOVA with Tukey’s post hoc test for multiple comparisons; #: significant versus sedentary standard-diet group, * p < 0.05 between compared groups.