Figure 7.

Genetic signature identified under the HIV-1 envelope GP120 V1 loop associate to clade B HIV-1 chronic compared to recent viruses. The X axis represents amino acids (AA) composing the V1 loop sequence (direction N to C). The Y axis represents the normalized AA frequency identified at each position of the V1 sequence for each category of infection. The top line box represents chronic virus envelope V1 loop sequences (N = 105) and the bottom for RC viruses within 136 days MDRI and TF (N = 126). As indicated for Weblogo analysis, the overall height of each stack indicates the sequence conservation at that position (measured in bits), whereas the height of symbols within the stack reflects the relative frequency of the corresponding amino or nucleic acid at that position. The glutamic acid (E) amino signature was localized at position 206 of alignment (HXB2 position 153E) and was identified by a red asterisk.