Figure 8.

Genetic signature identified under the HIV-1 envelope signal peptide (SP) associate to clade B HIV-1 chronic compared to recent viruses. The X axis represents amino acids (AA) composing the Env SP sequence (direction N to C). The Y axis represents the normalized AA frequency identified at each position of the SP sequence for each category of infection. The top line box represents chronic virus envelope SP sequences (N = 105) and the bottom for RC viruses within 136 MDRI and TF (N = 126). As indicated for Weblogo analysis, the overall height of each stack indicates the sequence conservation at that position (measured in bits), whereas the height of symbols within the stack reflects the relative frequency of the corresponding amino or nucleic acid at that position. The isoleucine (I) amino signature was localized at position 40 of alignment (HXB2 position M24I) and is identified by a red asterisk.