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. Author manuscript; available in PMC: 2020 May 20.
Published in final edited form as: Nature. 2019 Nov 20;576(7785):138–142. doi: 10.1038/s41586-019-1774-2

Extended Data Fig. 6 |. Body composition of PATKO mice fed a high-fat diet.

Extended Data Fig. 6 |

WT and PATKO mice were fed HFD for 20 weeks. a, Body weight progression (WT n = 7; PATKO n = 9). b, BAT of PATKO mice fed HFD is smaller compared to BAT of HFD-fed WT mice. No difference was seen in iWAT, eWAT, or liver weight (WT n = 7; PATKO n = 9). c, PATKO mice fed HFD had higher levels of plasma triglycerides and non-esterified fatty acids (NEFA) (WT n = 7; PATKO n = 8). d, H&E stain images of liver show increased steatosis in PATKO mice. Scale bar is 100 μm. Representative images of 7 biologically independent samples. e, PATKO mice fed HFD had more lipid accumulation in liver. (n = 8). a-e, Biologically independent samples. Data presented as mean ± s.e.m. *p<0.05 vs. WT determined by two-tailed Student’s t-test.