Table 3.
Effect of oral administration of DCM leaf extract of Gnidia glauca for 6 weeks on body weight of HFD-induced obese laboratory rats.
| TREAT-MENTS (mg/kg) | Weekly body weights of rats (g) |
||||||
|---|---|---|---|---|---|---|---|
| Day 1 | Day 7 | Day 14 | Day 21 | Day 28 | Day 35 | Day 42 | |
| Control | 191.3 ± 6.9b | 212.1 ± 10.1c | 219.4 ± 10.8bc | 223.9 ± 11.6b | 227.9 ± 11.8b | 230.1 ± 11.4b | 232.6 ± 11.2b |
| High-fat Diet | 233.9 ± 4.4a | 259.4 ± 4.9a | 265.1 ± 4.7a | 277.9 ± 1.9a | 288.8 ± 3.7a | 308.8 ± 3.4a | 325.6 ± 6.9a |
| Orlistat | 242.5 ± 10.1a | 239.7 ± 10.8ab | 235.2 ± 10.4b | 231.8 ± 8.4b | 223.9 ± 6.3b | 214.7 ± 7.7bc | 196.9 ± 6.7c |
| 200 mg/kg | 235.1 ± 11.4a | 222.3 ± 12.5bc | 214.9 ± 10.9c | 201.2 ± 11.9c | 192.7 ± 12.1c | 182.7 ± 13.5d | 170.6 ± 5.1d |
| 250 mg/kg | 248.6 ± 5.8a | 239.6 ± 5.9ab | 231.3 ± 4.9bc | 220.0 ± 3.8b | 206.4 ± 6.7c | 199.5 ± 8.3cd | 181.1 ± 5.3d |
| 300 mg/kg | 249.1 ± 9.4a | 240.7 ± 9.0a | 231.9 ± 7.6b | 217.8 ± 5.3b | 201.5 ± 7.7c | 191.2 ± 4.9d | 178.7 ± 7.5d |
Results are expressed as Means ± SD for five animals per group. The means of body weight of experimental animals within respective columns followed by superscript of a similar lower-case letter (such as [a & ab], [b, ab & bc], [c, bc & cd] or [d, cd]) are not significantly different from each other (p > 0.01). However, in each column, means followed by superscripts of different lower-case letter (such as a, b, c & d) are significantly different from each other (p ≤ 0.01). Inferential statistics were performed using One way-ANOVA to test for statistical differences among studied groups. Tukey's post hoc test was then done for pairwise separation and comparison of means.