Table 1.
Results of PantherDB analysis for the comparison between sham and acquisition groups
| PANTHER GO-Slim pathways | Over/Under | Fold enrichment | Raw p value |
FDR (q value) |
|
|---|---|---|---|---|---|
| Cellular Component | Postsynaptic membrane (GO:0045211) | + | 30.25 | 9.68E-11 | 3.10E-09 |
| Neuromuscular junction (GO:0031594) | + | 25.21 | 3.67E-04 | 2.14E-03 | |
| Synapse (GO:0045202) | + | 12.67 | 2.09E-11 | 1.34E-09 | |
| Dendrite (GO:0030425) | + | 9.71 | 7.15E-07 | 9.15E-06 | |
| Neuron projection (GO:0043005) | + | 7.03 | 8.27E-09 | 1.77E-07 | |
| Cell junction (GO:0030054) | + | 6.92 | 3.10E-04 | 1.98E-03 | |
| Cell projection (GO:0042995) | + | 4.9 | 3.05E-07 | 4.88E-06 | |
| Integral to membrane (GO:0016021) | + | 2.69 | 3.03E-05 | 2.42E-04 | |
| Plasma membrane (GO:0005886) | + | 2.43 | 4.05E-06 | 3.70E-05 | |
| Cytoskeleton (GO:0005856) | + | 2.31 | 9.41E-03 | 4.63E-02 | |
| Membrane (GO:0016020) | + | 2.14 | 3.70E-06 | 3.94E-05 | |
| Protein complex (GO:0043234) | + | 2.1 | 0.0001 | 7.14E-04 | |
| Biological Process | Growth (GO:0040007) | + | 44.12 | 9.25E-05 | 2.51E-03 |
| Asymmetric protein localization (GO:0008105) | + | 35.29 | 1.58E-04 | 3.86E-03 | |
| Muscle organ development (GO:0007517) | + | 26.14 | 3.03E-07 | 1.85E-05 | |
| Neuron-neuron synaptic transmission (GO:0007270) | + | 13.07 | 1.27E-08 | 1.55E-06 | |
| Pyrimidine nucleobase metabolic process (GO:0006206) | + | 11.39 | 2.91E-03 | 3.55E-02 | |
| Synaptic transmission (GO:0007268) | + | 6.38 | 4.01E-11 | 9.80E-09 | |
| Ion transport (GO:0006811) | + | 4.48 | 2.13E-06 | 8.66E-05 | |
| Cell-cell signaling (GO:0007267) | + | 4.43 | 2.12E-08 | 1.72E-06 | |
| Cytoskeleton organization (GO:0007010) | + | 3.22 | 1.35E-03 | 2.20E-02 | |
| Protein localization (GO:0008104) | + | 2.88 | 1.20E-03 | 2.08E-02 | |
| Transport (GO:0006810) | + | 2.35 | 4.58E-06 | 1.60E-04 | |
| Localization (GO:0051179) | + | 2.34 | 9.21E-07 | 4.50E-05 | |
| Neurological system process (GO:0050877) | + | 2.11 | 3.25E-04 | 7.21E-03 | |
| System process (GO:0003008) | + | 2.05 | 4.42E-04 | 8.30E-03 | |
| Phosphate-containing compound metabolic process (GO:0006796) | + | 1.94 | 1.45E-03 | 2.09E-02 | |
| Cellular component organization (GO:0016043) | + | 1.76 | 2.71E-03 | 3.48E-02 | |
| Cell communication (GO:0007154) | + | 1.55 | 3.25E-03 | 3.77E-02 | |
| Sensory perception of smell (GO:0007608) | - | <0.01 | 2.15E-03 | 2.92E-02 | |
| Sensory perception of chemical stimulus (GO:0007606) | - | <0.01 | 1.44E-03 | 2.19E-02 | |
| Sensory perception (GO:0007600) | - | <0.01 | 0.000426 | 0.00866 | |
| Molecular Function | Glutamate receptor activity (GO:0008066) | + | 22.96 | 7.33E-09 | 3.50E-07 |
| Nucleotide kinase activity (GO:0019201) | + | 20.17 | 1.16E-06 | 3.70E-05 | |
| Voltage-gated calcium channel activity (GO:0005245) | + | 13.07 | 2.02E-03 | 3.51E-02 | |
| Ligand-gated ion channel activity (GO:0015276) | + | 9.8 | 3.71E-08 | 1.42E-06 | |
| Voltage-gated ion channel activity (GO:0005244) | + | 8.11 | 1.37E-04 | 2.91E-03 | |
| Voltage-gated potassium channel activity (GO:0005249) | + | 7.59 | 2.34E-03 | 3.44E-02 | |
| Ion channel activity (GO:0005216) | + | 7.13 | 1.86E-11 | 3.56E-09 | |
| Cation channel activity (GO:0005261) | + | 5.12 | 3.51E-03 | 4.19E-02 | |
| Small GTPase regulator activity (GO:0005083) | + | 4.64 | 2.25E-03 | 3.59E-02 | |
| Transmembrane transporter activity (GO:0022857) | + | 3.8 | 4.03E-09 | 3.84E-07 | |
| Transporter activity (GO:0005215) | + | 3.54 | 4.84E-09 | 3.08E-07 | |
| GTPase activity (GO:0003924) | + | 3.13 | 1.67E-03 | 3.19E-02 | |
| Kinase activity (GO:0016301) | + | 2.52 | 2.41E-03 | 3.29E-02 | |
| Pyrophosphatase activity (GO:0016462) | + | 2.38 | 3.84E-03 | 4.31E-02 | |
| Catalytic activity (GO:0003824) | + | 1.74 | 3.98E-06 | 1.08E-04 | |
| Protein binding (GO:0005515) | + | 1.64 | 0.00313 | 0.0399 | |
*
See Extended Data Table 1-1 for all Reactome pathway terms identified from the comparison between sham and acquisition groups.