Table 2.
Genotype distribution and allele frequency in OSA and controls.
| SNP | Genotype/Allele | Control | OSA | Crude OR | P value | Adjusted OR | P value |
|---|---|---|---|---|---|---|---|
| N = 100 | N = 94 | (95% CI) | (95% CI) | ||||
| Rs841 | GG | 63 (63%) | 59 (62.8%) | 1.00 (Reference) | |||
| GA | 33 (33%) | 32 (34%) | 1.03 (0.55–1.92) | 0.9 | 1.64 (0.3–8.79) | 0.56 | |
| AA | 4 (4%) | 3 (3.2%) | 0.8 (0.19–3.09) | 0.77 | 1.59 (0.28–8.83) | 0.59 | |
| Dominant | |||||||
| GG | 63 (63%) | 59 (62.8%) | 1.00 (Reference) | ||||
| GA + AA | 37 (37%) | 35 (37.2%) | 1.01 (0.56–1.79) | 0.97 | 0.93 (0.5–1.71) | 0.82 | |
| Recessive | |||||||
| GG + GA | 96 (96%) | 91 (96.8%) | 1.00 (Reference) | ||||
| AA | 4 (4%) | 3 (3.2%) | 0.79 (0.19–3.01) | 0.76 | 0.61 (0.11–3.25) | 0.56 | |
| G | 159 (79.5%) | 150 (79.8%) | 1.00 (Reference) | ||||
| A | 41 (20.5%) | 38 (20.2%) | 0.98 (0.6–1.58) | 0.94 | 0.74 (0.3–1.81) | 0.51 | |
| A930G p22phox | GG | 29 (29%) | 27 (28.7%) | 1.00 (Reference) | |||
| GA | 48 (48%) | 53 (56.4%) | 1.18 (0.6–2.33) | 0.6 | 1.18 (0.6–2.32) | 0.63 | |
| AA | 23 (23%) | 14 (14.9%) | 0.65 (0.26–1.43) | 0.32 | 0.68 (0.28–1.68) | 0.41 | |
| Dominant | |||||||
| GG | 29 (29%) | 27 (28.7%) | 1.00 (Reference) | ||||
| GA + AA | 71 (71%) | 67 (81.3%) | 1.01 (0.55–1.86) | 0.96 | 1.03 (0.54–1.97) | 0.92 | |
| Recessive | |||||||
| GG + GA | 77 (77%) | 80 (85.1%) | 1.00 (Reference) | ||||
| AA | 23 (23%) | 14 (14.9%) | 0.58 (0.28–1.23) | 0.15 | 0.61 (0.28–1.34) | 0.22 | |
| G | 106 (53%) | 107 (57%) | 1.00 (Reference) | ||||
| A | 94 (47%) | 81 (43%) | 0.85 (0.57–1.26) | 0.43 | 0.82 (0.53–1.28) | 0.4 | |
| Rs1799983 | GG | 69 (69%) | 51 (54.2%) | 1.00 (Reference) | |||
| GT | 28 (28%) | 37 (39.4%) | 1.78 (0.96–3.24) | 0.06 | 1.55 (0.82–2.93) | 0.17 | |
| TT | 3 (3%) | 6 (6.4%) | 2.7 (0.71–10.17) | 0.15 | 3.57 (0.82–15.48) | 0.08 | |
| Dominant | |||||||
| GG | 69 (69%) | 51 (54.2%) | 1.00 (Reference) | ||||
| GT+TT | 31 (31%) | 45 (45.8%) | 1.96 (1.11–3.55) | 0.02 | 3.17 (0.07–1.14) | 0.93 | |
| Recessive | |||||||
| GG + GT | 97 (97%) | 88 (83.6%) | 1.00 (Reference) | ||||
| TT | 3 (3%) | 6 (6.4%) | 2.2 (0.57–8.2) | 0.26 | 0.32 (0.07–1.37) | 0.12 | |
| G | 166 (83%) | 139 (74%) | 1.00 (Reference) | ||||
| T | 34 (17%) | 49 (26%) | 1.72 (1.04–2.81) | 0.02 | 2.12 (0.46–9.74) | 0.33 |
SNP: Single Nucleotide Polymorphism, OSA: Obstructive Sleep Apnea, OR: Odd Ratio, CI: Confidence Interval. Adjusted odds ratio were adjusted for body mass index.