Figure 4.

Spatiotemporal GF deliveryfrom tissue engineered rotator cuff scaffolds reconstructing native-like collagen organization at the tendon-to-bone interface. Circularly polarized microscopy images show enhanced alignment of collagen fibers in +GF compared with −GF (a). Automated digital imaging processing showed a narrower angular distribution of collage fibers in native and +GF compared with −GF (b). Quantitatively, angular deviation was significantly lower in native and +GF compared with −GF (c) (error bars indicate the standard deviation: *p < 0.05 compared with all other groups; n = 6 per group).