Figure 2.

Micelle Morphology, In Vitro Photothermal Properties, as well as Photo- and Bio-stability of DSPE-PEG@ICG-J

(A) Transmission electron microscopic image and dynamic light scattering analysis result (inset) of DSPE-PEG@ICG-J.

(B) Temperature profiles of PBS buffer (blue dashed line) and DSPE-PEG@ICG-J solutions at different concentrations (blue solid line) under the irradiation of 880-nm laser (0.8 W·cm⁻²), as well as of PBS buffer (red dash) and free ICG at 50 μg·mL⁻¹ (red solid line) under the irradiation of 808-nm laser (0.8 W·cm⁻²).

(C–G) (C) The temperature profiles of DSPE-PEG@ICG-J and free ICG at 50 μg·mL⁻¹ under five cycles of laser on-off (0.8 W·cm⁻²; 880-nm laser for DSPE-PEG@ICG-J; 808-nm laser for free ICG). The absorption spectra of (D) free ICG and (E) DSPE-PEG@ICG-J before and after 10-min laser irradiation, and the inserts show the before (left) and after (right) photographs. The stability of DSPE-PEG@ICG-J when incubated in (F) 10% fetal bovine serum or (G) with A549 cells.

(H) The fluorescence profiles of DSPE-PEG@ICG-J (left) and free ICG (right) after they were intravenously injected into mice (150.0 μL, at ICG equivalent concentration of 0.5 mg·mL⁻¹).

See also Figures S4 and S5.