Table 1.

The mechanisms and related renal disease models of NLRP3 inhibitors.

NLRP3 Inhibitors	Mechanisms	Renal Disease Models
Tranilast	Inhibition of NLRP3-NLRP3	UUO [106]
	and NLRP3-ASC interactions	5/6 nephrectomy [107]
		Diabetic nephropathy [108]
BAY 11-7082	Inhibition of NLRP3 ATPase	HFD nephropathy [109]
		Lupus nephritis [82]
		Diabetic nephropathy [110]
MCC950	Blockade of ATP hydrolysis	Salt-sensitive hypertension [93]
	in NLRP3 NACHT domain	Crystal nephropathy [8]
		Lupus nephritis [83]
		Diabetic nephropathy [29]
BHB	Inhibition of ASC oligomerization	Crystal nephropathy [17]

BHB = β-Hydroxybutyrate, HFD = high-fat diet, UUO = unilateral ureteral obstruction.