Table 3. Comparison of the different diagnostic criteria suggested for pyoderma gangrenosum 31, 34, 35.
Proposed diagnostic criteria | ||
---|---|---|
Su et al. 34 criteria | The Delphi Consensus of
International Experts |
PARACELSUS score |
Major criteria | ||
Other ulcerating conditions excluded (that is,
biopsy and other investigations) |
Biopsy | Exclude other differential diagnoses |
Typical clinical presentation of classic
pyoderma gangrenosum a |
Reddish-violaceous ulcer border | |
Progressive ulceration
(developed in <6 weeks) |
||
Minor criteria b | ||
Histopathology findings | Histopathology findings | Histopathology findings |
Typical systemic diseases present | Typical systemic diseases present | Typical systemic diseases present
inflammatory bowel disease, inflammatory arthritis |
Treatment responsive to systemic steroids | Treatment responsive to
immunosuppressants |
Improvement in symptoms by
immunosuppressants |
History of pathergy and cribiform scarring | Pathergy | Pathergy |
Cribiform scarring | ||
Pain, undermined border, peripheral
erythema |
Undermined border | |
Pain | ||
Papule, pustule, or vesicle that
ulcerated |
Irregular ulcer shape | |
Multiple ulcerations (at least one on
lower leg) |
aProgressive (1 to 2 cm/day or increase by 50% in 1 month), painful, irregular and undermined border, violaceous color, preceded by papule, pustule, or bulla.
bFor the PARACELSUS score, minor criteria have a white background and additional criteria have a gray background.