Table 1.
Weighted baseline characteristics of the study population including derivation and validation datasets
| Examination years | Examination age (years) | Age <45 years | Age 45–59 years | Age ≥60 years | Female | SCORE | PCE | BMI (kg/m2) | Hypertension | Diabetes | Daily smoker | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All (n=398 846) | 1970–2013 | 51·0 (40·7–59·7) | 118 731 (32·9%) | 179 265 (42·8%) | 100 842 (24·3%) | 184 055 (48·7%) | 1·0 (0·2–3·6) | 4·3 (1·2–11·4) | 25·7 (23·1–28·8) | 162 632 (40·1%) | 18 656 (4·8%) | 130 940 (33·3%) |
| Numbers available | 377 596 (95·3%) | 398 838 (>99·9%) | 398 838 (>99·9%) | 398 838 (>99·9%) | 398 838 (>99·9%) | 398 846 (100·0%) | 357 911 (81·4%) | 277 278 (62·7%) | 395 505 (99·2%) | 388 941 (97·8%) | 384 164 (96·5%) | 387 447 (97·4%) |
| Derivation (n=199 415) | 1970–2013 | 51·0 (40·9–59·7) | 59 387 (32·5%) | 89 676 (43·1%) | 50 348 (24·4%) | 91 786 (48·4%) | 1·0 (0·2–3·6) | 4·3 (1·2–11·4) | 25·8 (23·1–28·8) | 81 279 (40·3%) | 9245 (4·8%) | 65 640 (33·8%) |
| Numbers available | 188 767 (95·2%) | 199 411 (>99·9%) | 199 411 (>99·9%) | 199 411 (>99·9%) | 199 411 (>99·9%) | 199 415 (100·0%) | 178 980 (82·0%) | 138 663 (63·3%) | 197 767 (99·2%) | 194 534 (97·8%) | 192 097 (96·4%) | 193 708 (97·4%) |
| Validation (n=199 431) | 1970–2013 | 50·9 (40·6–59·6) | 59 344 (33·3%) | 89 589 (42·5%) | 50 494 (24·2%) | 92 269 (49·1%) | 1·0 (0·2–3·6) | 4·3 (1·2–11·4) | 25·7 (23·2–28·9) | 81 353 (40·0%) | 9411 (4·7%) | 65 300 (32·8%) |
| Numbers available | 188 829 (95·3%) | 199 427 (>99·9%) | 199 427 (>99·9%) | 199 427 (>99·9%) | 199 427 (>99·9%) | 199 431 (100·0%) | 178 931 (80·9%) | 138 615 (62·2%) | 197 738 (99·2%) | 194 407 (97·8%) | 192 067 (96·6%) | 193 739 (97·5%) |
| p value | 0·51 | 0·63 | 0·49 | 0·44 | 0·66 | 0·43 | 0·85 | 0·76 | 0·85 | 0·70 | 0·66 | 0·19 |
Data are n (%) for numbers available, median (IQR) for continuous variables (except for examination years where the range is given), n (%) of participants or % (95% CI) for categorical variables. p values are given for the validation cohort versus the derivation cohort using weighted versions of the Mann-Whitney and χ2 test. Due to the presence of the Estonian case-cohort dataset, the summary estimates (% and median [IQR]) are weighted by the inverse of the inclusion probability for individuals in that cohort. The individuals from other cohorts are given weight 1 in the computation. Totals (n) are not weighted. From the Estonian data only, the sub-cohort is used in the table computations. SCORE=Systematic Coronary Risk Estimation. PCE=Pooled Cohort Equations. BMI=body-mass index.