EE-related change in tissue weight, as measured at sacrifice. (A) Brown adipose tissue (BAT) weight. (B) Inguinal white adipose tissue (iWAT) weight. (C) Gonadal white adipose tissue (gWAT) weight. (D) Retroperitoneal white adipose tissue (rWAT) weight. (E) Liver tissue weight. Data are means ± SEM. Males: n=8 SE, n=9 EE. Females: n=10 SE, n=9 EE. * P<0.05, ** P<0.01, *** P<0.001, **** P<0.0001.