Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic illustration of AHR activation modulating HIV-1 transcription. AHR activation stimulated with Trp metabolites (FICZ and Kyn) increases AHR nuclear translocation; accumulation of heterodimers of AHR/ARNT at the nucleus facilitates Tat-mediated recruitment of P-TEFb to HIV-1 5ˊ-LTR for enhancing the phosphorylation of RNA Pol II and its association with the 5ˊ-LTR promoter. CTD, C-terminal domain of RNA Pol II; Nuc: nucleosome; TAR, transactivation response element.
