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. 2019 Dec 16;29(12):1792–1803. doi: 10.1089/thy.2019.0328

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Copyright 2019, Mary Ann Liebert, Inc., publishers

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FIG. 2. — Percentage of papillae within the tumor, nodal metastasis, and BRAF/NRAS mutation. (A) Papillae within the tumor and risk of nodal metastasis. (B) Papillae within the tumor and BRAF^V600E/NRAS^Q61R status subdivided to BRAF^V600E positive, NRAS^Q61R positive and negative for both immunostains; on the y axis, the tumor groups are subdivided based on the percentage of papillae, and the x axis shows the number of tumors. (C) Diagram showing how an increasing percentage of papillae within the tumor is associated with a higher rate of N1 disease, BRAF^V600E, and a lower frequency of NRAS^Q61R. The BRAF and NRAS mutational status was determined by immunohistochemistry using monoclonal antibodies for BRAF^V600E and NRAS^Q61R in a subset of 100 randomly selected cases.