Table 1.
The PK and PD data following instillation of Sucrose laurate (SL) with insulin (50 IU/kg) to rat colon (i.c.) or jejunum (i.j.). Relative bioavailability (% F) and pharmacological availability (% PA) were calculated relative to s.c. injection of insulin (1 IU/kg). Statistical analysis is shown in Tables S2–S5.
| Treatment | Cmax (mU/L) | Tmax (min) |
AUC(0–120) (mU/L·min) |
% F | % PA |
|---|---|---|---|---|---|
| 1 IU/kg (s.c.) | 111 ± 26 | 20 ± 0 | 6936 ± 2436 | - | - |
| 50 mM SL (i.j.) | 118 ± 74 | 20 ± 16 | 4616 ± 1171 | 1.3 | 1.7 |
| 100 mM SL (i.j.) | 156 ± 80 | 30 ± 13 | 8782 ± 3007 | 2.5 | 2.4 |
| 50 mM C10 (i.j.) | 276 ± 54 | 43 ± 12 | 15,210 ± 5831 | 4.4 | 2.8 |
| 100 mM C10 (i.j.) | 215 ± 57 | 43 ± 13 | 11,348 ± 4489 | 3.3 | 2.5 |
| 1 mM SL (i.c.) | 179 ± 30 | 73 ± 13 | 9382 ± 2400 | 2.7 | 1.9 |
| 10 mM SL (i.c.) | 241 ± 59 | 37 ± 13 | 14,679 ± 6068 | 4.2 | 2.5 |
| 25 mM SL (i.c.) | 459 ± 52 | 23 ± 3 | 30,954 ± 4087 | 8.9 | 2.7 |
| 50 mM SL (i.c.) | 216 ± 2 | 33 ± 7 | 14,456 ± 2167 | 4.2 | 2.9 |
| 10 mM C10 (i.c.) | 293 ± 30 | 47 ± 0 | 21,395 ± 6966 | 6.2 | 2.1 |
| 25 mM C10 (i.c.) | 304 ± 52 | 37 ± 7 | 16,138 ± 5476 | 4.7 | 2.6 |