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. 2019 Nov 17;11(11):615. doi: 10.3390/pharmaceutics11110615

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cell viability and migration were inhibited by the siRNA delivered by nanoparticles. (a) The cell viability examined by cell counting kit-8 assay (CCK-8). * p < 0.05 compared with nanoparticle+NC group; (b) the cell migration analyzed by the transwell assay; (c) the representative images of migrated cells in the transwell assay. Bar indicates 100 μm. (d) The cell cycle distribution analyzed by PI staining followed by flow cytometry. G1 phase arrest and G2 phase arrest were observed upon nanoparticle-delivered siBCL2 and siBIRC5, respectively.