Skip to main content
NCBI home page
ACS Omega logoLink to ACS Omega
. 2019 Dec 4;4(25):21267–21278. doi: 10.1021/acsomega.9b02770

Biomolecule-Mediated Generation of Ru Nanocatalyst for Sustainable Reduction of Nitrobenzene

Pritam Singh †, Mita Halder †, Santanu Ray ‡, Bilwadal Bandyopadhyay §, Kamalika Sen †,*
PMCID: PMC6921630  PMID: 31867521

Abstract

graphic file with name ao9b02770_0015.jpg

A mild and sustainable synthetic route was followed for the generation of biomolecule-assisted Ru nanocatalyst under open as well as inert atmosphere using the polyphenol morin. The nanocatalyst was characterized thoroughly by powder X-ray diffraction, N2 adsorption–desorption, high-resolution transmission electron microscopy, dynamic light scattering, X-ray photoelectron spectroscopy, absorption spectroscopy, Fourier transform infrared spectroscopy, fluorescence spectroscopy, thermogravimetric analysis, and inductively coupled plasma optical emission spectrometry. The nanocatalyst reveals excellent catalytic activity for the reduction of several substituted nitrobenzene to aniline derivatives under simple, mild, and environment-friendly conditions. The catalyst can be reused for four consecutive cycles without significant loss in its catalytic activity.

Introduction

Study related to nanocatalysts (NCs) is one of the most attractive and frontline areas of modern research due to their diverse applications in innumerable branches of science. The unique properties of NCs, including large surface-to-volume ratio and numerous accessible active sites compared to their bulk counterparts, make these materials most favorable for organic transformations. Organic transformations using NCs are in vogue as they offer several benefits like excellent atom economy, placid reaction conditions, ease of separation of the synthesized products as well as catalysts, etc.1−3 Therefore, extensive research for efficient design and sustainable production of highly active metal or metal oxide NCs is exceedingly worthwhile. Several literature reports are available describing novel methods for the synthesis of metal-based NCs.4−8 Nanodimensional noble metals, mainly palladium, platinum, and ruthenium have captured significant interest, due to their high activity and selectivity toward several catalytic processes,9,10 including selective hydrogenation of chloro nitrobenzene (p-CNB).11 Although ruthenium is a low-cost material, a recyclable Ru-based catalyst would make the methodology many-fold cost-effective, environment-friendly, and industrially efficient. The widely studied methods for the generation of nanodimensional Ru catalyst utilize the conventional reduction process with drastic reaction conditions.11,12

Reduction using biomolecules has gradually captured the limelight of researchers due to the increasing environmental, economic, as well as industrial concern. In this connection, plant extract or plant-mediated materials have revealed their capability to convert metal ions into their nanostate often through a simple process without requirement of any rigorous experimental setup. Significantly, phytochemicals like polyphenols, phenolic acids, alkaloids, terpenoids, sugars, etc., present in plant metabolites, probably partake in the biosynthesis of metal and/or metal oxide nanoparticles (NPs). In an effort to harness such nanodimensional Ru, Kannan and Sundrarajan have reported the synthesis of ruthenium oxide NPs using Acalypha indica plant extract,13 wherein they studied the antimicrobial activity of the NPs. Ismail et al. have reported a green synthesis of ruthenium oxide NPs using aqueous extract of Aspalathus linearis and deposited over nickel foam to develop a supercapacitor.14 Synthesis of Se/Ru alloy was reported by Zhou et al., with the help of gallic acid as both reducing and stabilizing agent,15 which was further studied for the possibility of its biomedical applications. Reports on green syntheses of nanodimensional ruthenium for catalytic applications are scarce excepting a few.16,17 Generation of nanodimensional Ru employing the vast family of biomolecules still remains to be unveiled and explored for their magnificent catalytic properties. Some literature reports are tabulated here, which describe the syntheses of Ru-NCs under different conditions (Table 1).

Table 1. List of Some Possible Ways of Synthesis of Ru NCs Found in the Literature.

entry synthetic condition oxidation state of Ru ref
1 Aqueous solution of RuCl3 and A. indica leaf extract were mixed and then stirred at 80 °C for 2 h. The solid mass was collected after centrifugation. Finally, the nanomaterial was obtained after calcination at 600 °C; IV (13)
2 RuCl3 aqueous solution was added to Aspalathus linearis extract at pH 3.8. Then, the mixture was stirred at room temperature with reaction time 2 h; IV (14)
3 Aqueous solution of gallic acid, Na2SeO3, and RuCl3 were mixed together at pH 3 under heating at 70 °C. The excess gallic acid and Na2SeO3 were removed by dialysis;   (15)
4 RuCl3 was taken in colloidal aqueous solution of graphene oxide. The mixture was stirred for 1 h. After heating at 400 °C for 2 h in an autoclave, the solid was washed and dried at 60 °C;   (17)
5 Solid RuCl3 was mixed thoroughly with solid NaBH4 under solventless condition. The mixture was washed with ethanol and centrifuge to collect the solid mass. Finally, the solvent was removed through vacuum drying; 0 (18)
6 Silica support was added to aqueous solution of RuCl3. The mixture was sonicated. NaBH4 solution was added to this suspension with stirring. The solid mass was separated using a magnet, washed with water, and finally vacuum-dried at 60 °C. 0 (19)
Open in a new tab

Formation of aniline derivatives is of significant interest due to the pharmaceutical as well as industrial concerns.20,21 Aniline and its derivatives widely participate in the synthesis of several valuable compounds, including pharmaceuticals, pigments, pesticides, herbicides, rigid polyurethane, etc.20−23 Aniline acts as the building block for the synthesis of different peptides, amino acids, etc.24 Moreover, synthesis of aniline derivatives is crucial due to its manifold applications in various fields such as production of consumer goods, adhesives/sealants, coatings, textile materials, pulp and care, rubber products, electronic goods, etc.25 Aromatic amines are usually prepared from catalytic reduction of nitroarenes in the presence of H2 gas, NaBH4, and N2H4 as reducing agent together with a catalyst, viz., ruthenium, SBA-15, carbon nanotubes, etc.26−36

In the present study, we have described an efficient green synthesis of ruthenium nanocatalysts using a flavonoid-type biomolecule, morin as stabilizing agent at room temperature (Scheme 1). The synthesis has been done both in open atmosphere and in N2 environment. Morin is a naturally available polyphenol commonly obtained from Maclura pomifera and Maclura tinctoria and from the leaves of Psidium guajava.(37) It can act as a reducing as well as stabilizing agent during nanosynthesis. Thereafter, the as-synthesized nanomaterials have been employed for the reduction of nitroarenes to furnish aromatic amines and their derivatives with good to excellent product yields.

Scheme 1. General Reaction Scheme for the Reduction of Nitrobenzene to Aniline Using Ruthenium-NCs.

Scheme 1

Open in a new tab

Characterization

Absorption Spectroscopy

Absorption spectroscopy was used to find the best condition for the preparation of NCs. The time scan data established the possible mechanism behind the formation of the NCs. To get the best condition of NC formation, 0.2 mL of 10 mM alcoholic solution of morin was taken in 2.5 mL solution of different pH values (viz., 5, 7, 9, and 12). The alcoholic solution of morin has its characteristic absorption maximum at ∼330 nm. Then, 0.01 mL portion of 1 mM RuCl3 solution was gradually added to the above morin-containing solution of different pH values.

N2 Adsorption–Desorption and BET Analysis

N2 adsorption–desorption was performed using the solid sample to determine the specific surface properties of the material. The specific surface area, pore size distribution, and pore volume of the solid material can be obtained after degassing the material at 300 °C in a surface area analyzer instrument for 3 h. Finally, the specific surface area of the NCs can also be obtained using Brunauer–Emmett–Teller (BET) method.

TEM analysis

The TEM analysis was performed after dispersing 2 mg of the NC in 2 mL of water–alcohol (1:1) mixture and sonicating for 1 h. Then, the dispersed solution was drop-cast on a carbon-coated Cu grid. Before getting the TEM images of the material, the grid was dried under an IR lamp.

FTIR Analysis

FTIR analysis was used to get an idea about the bond vibrations of the NCs. A very small amount of the solid material was thoroughly mixed with dry KBr using a mortar and pestle. The sample was then pelletized using pressure around 5 ton using a hydraulic press. The pellet was then loaded in the sample holder of the analyzer instrument.

Powder XRD

Powder XRD was used to determine the crystalline nature of the prepared NCs. Powder sample was taken in a rectangular metal holder and then the arrangement was lightly pressed before the X-ray crystallographic analysis.

Dynamic Light Scattering (DLS)

Dynamic light scattering experiment was carried out to estimate the hydrodynamic radii of the NCs. The sample preparation method is similar to that of the TEM experiment. The dispersed solution obtained after sonication for 1 h was further diluted ∼100 times to perform the experiment.

Thermogravimetric Analysis (TGA)

The thermal properties of the NC were determined using the thermogravimetric analysis technique under N2 atmosphere with a flow rate of 10 mL/min. An ∼6 mg of solid sample was taken on a platinum pan and heated to ∼439 °C at a heating rate of 10 °C/min to record the change of weight percentage with the change of temperature.

X-ray Photoelectron Spectroscopy (XPS) Analysis

The elemental composition and the oxidation state of the central metal ion were analyzed using this technique. A monochromated Al Kα was used as X-ray source with X-ray spot size of 900 × 900 μm2 outfitted with the XPS instrument. A flood gun was used for uniform charge neutralization. The binding energies (BEs) of Ru 3d (∼280 eV), C 1s (∼285 eV), N 1s (∼400 eV), and O 1s (∼531 eV) were obtained using both full survey and narrow scan methods. The full survey scan was repeated five times with step size of 1 eV, pass energy of 150 eV, and dwell time of 50 ms, whereas the narrow scan was repeated 15 times with step size and pass energy of 0.1 and 20 eV, respectively, and dwell time of 100 ms. Due to the very close binding energy of Ru 3d and C 1s, Ru 3p (BE ∼475 eV) was also acquired using the narrow scan method. All of the data were examined using Thermo Avantage Software (version 5.952) taking a smart background.

ICP-OES Analysis

Inductively coupled plasma optical emission spectrometry (ICP-OES) was used to determine the amount of ruthenium in the catalyst and also the leaching percentage of the Ru from the catalyst after the reaction. To get the amount of ruthenium in the catalyst, 6 mg of solid catalyst was digested in hot and concentrated HNO3. To achieve leaching of the catalyst, 6 mg of the catalyst was treated with nitrobenzene, water, and reducing agent as in the reaction mixture (as described in the following section). After the reaction was complete, the reaction mixture was centrifuged. The reaction mixture was collected separately, and the solid catalyst was again washed with water and then centrifuged again. Finally, the reaction mixture was digested with hot and concentrated HNO3. After three successive addition and evaporation of concentrated acid, the solid masses so obtained were cooled to room temperature. Finally, the solid masses were treated with a requisite amount of Milli-Q water. Then, the aqueous solutions were filtered using a microsyringe filter (pore size, 0.22 μm). The filtrates were then diluted with water to a particular volume, and then the solutions were introduced in the ICP-OES instrument.

Catalytic Activity for Reduction of Nitrobenzene to Aniline

The NCs designated as Ru-morin@air and Ru-morin@N2 were studied for their catalytic activities toward reduction of nitrobenzene to aniline in the presence of NaBH4 as a reducing agent and water as a solvent at 100 °C. After completion of the reaction (as indicated by TLC), and separation of the catalyst, the reaction mixture was extracted using ethyl acetate (3 × 10 mL). The organic part was washed with water and dried using anhydrous sodium sulfate. Then, the solvent was evaporated under reduced pressure to get the solid mass that was purified by column chromatography using pet ether and ethyl acetate as eluent to get the pure product. The identity of the product was confirmed by 1H and 13C NMR spectroscopy.

Recycling Experiment

At the end of the reaction, Ru-morin@N2 NC was separated from the reaction medium by centrifugation. Particularly, Ru-morin@N2 NC was chosen for the recycling experiment as it showed better catalytic activity. The collected NC was repetitively rinsed with water and ethyl acetate, followed by diethyl ether. Finally, the NC was dried at 80 °C temperature for 1 h to activate for the next run.

Results and Discussion

Absorption Spectroscopy

The best condition for the formation of the NC was pH 12, as indicated by the absorption spectra. At this pH, a sharp increase in the absorbance (λmax = 330 nm) occurred with gradual addition of RuCl3 solution to the morin solution of pH 12. The Benesi–Hildebrand (B–H) (Figure 1 and inset) plot indicates that the stoichiometry and the association constant for the interaction between ruthenium and morin at pH 12 were 1:1 and 1235.83 M–1, respectively, using eq 1

graphic file with name ao9b02770_m001.jpg 1

where A0 is the absorbance of morin solution in the absence of ruthenium, A1 is the absorbance of morin solution when it is completely bound with ruthenium, A is the absorbance of morin solution with gradual addition of ruthenium, [M] is the concentration of ruthenium, and Ka is the binding or association constant.38

Figure 1.

Figure 1

Open in a new tab

UV interaction data and B–H plot (inset) between morin (79–76 μM) and ruthenium (4–30 μM) at pH 12.

The absorption spectral changes of morin solution at pH values 5, 7, and 9 with increasing Ru concentration were insignificant and are pictorially described in supplementary figures (Figures S1–S3).

Mechanism of Formation of NCs

The possible mechanism for the formation of NC was established using time-dependent absorption spectroscopy. To study the mechanism, the metal solution and alcoholic solution of morin were taken in equimolar ratio at pH 12 in a cuvette and then the absorbance value of the resulting solution was measured at 330 nm continuously up to 4.5 h (Figure 2). The initial hike followed by achieving a maximum suggested an increase in monomer concentration which resulted due to burst nucleation governed by the LaMer mechanism. Thereafter, a steady increase in the absorbance for ruthenium-morin NC proposed a rapid autocatalytic growth according to the Finke–Watzky model.39

Figure 2.

Figure 2

Open in a new tab

Time scan profile for Ru-morin@air NC material at pH 12.

N2 Adsorption–Desorption and BET Analysis

The catalytic activity of porous materials may be related to their surface activity, which is again dependent on their pore diameter. This can be found in agreement with earlier studies.40,41 The catalyst in this was also found to be mesoporous as can be seen from the results of BET analysis. Figure 3 represents the N2 adsorption–desorption curve of the Ru-morin@air and Ru-morin@N2 NCs. From the figure, it is clear that the surface properties of Ru-morin@air show a convex type of isotherm with a blunt knee at a lower P/P0 value and an elevated adsorption at higher P/P0 value. This type of isotherm (type II) is generally obtained for unhampered monolayer–multilayer adsorption at high P/P0. The small knee indicates a major overlap of monolayer adsorption and initiation of multilayer adsorption. The width of the adsorption layer increased at P/P0 = 1. An H3 hysteresis loop was obtained for Ru-morin@air which is typical for nonrigid platelike assembly at the surface of the NCs. The adsorption–desorption study for Ru-morin@N2 shows type IV isotherm with H4 hysteresis loop. This type of isotherm is common for mesoporous adsorbent in which the adsorbent–adsorptive interaction plays a key role in determining the adsorption behavior of the adsorbent. Similar to type II isotherm, the monolayer–multilayer adsorption takes place by the pore condensation phenomenon. The H4 hysteresis loop has the characteristics of aggregated particles as obtained from TEM study also (discussed in the following section).42 For Ru-morin@N2, the change of the nature of the isotherm and the hysteresis loop is also in agreement with the change of surface morphology in inert atmosphere.43 The BET specific surface areas of Ru-morin@air and Ru-morin@N2 NCs are 4.72 and 24.11 m2/g, respectively. The porous nature of each of the adsorbent is obtained from this characterization and shows the average pore diameter for Ru-morin@air and Ru-morin@N2 to be 8.33 and 7.82 nm, respectively.

Figure 3.

Figure 3

Open in a new tab

N2 adsorption–desorption isotherm of Ru-morin@air and Ru-morin@N2NCs.

TEM Analysis

Figure 4 represents the TEM images of the prepared NCs, Ru-morin@air, and Ru-morin@N2 and confirms that they are formed in nanodimensions. The TEM images indicate significant differences for Ru-morin@air and Ru-morin@N2. For Ru-morin@air, frail lattice fringes with nanocrystalline and fine porosity were observed. However, for Ru-morin@N2, the TEM image shows an aggregated mass of the NCs with hardly any nanocrystallinity. The selected area electron diffraction (SAED) pattern (Figure 5) of the NCs reflected the same observation as from the TEM images. The particle size of the NCs was estimated using histogram analysis. From the histogram data, we obtained that the average particle size of Ru-morin@air and Ru-morin@N2 lies in the range of 20–10 nm (Figure 6). There is a slight decrease in average particle size in N2 atmosphere. However, there is an enhanced tendency for agglomeration in inert atmosphere, which arises due to higher interparticle interactions in the inert atmosphere.43,44 These results are in good agreement with the literature reports that suggest the change of surface morphology with the implementation of inert atmosphere.

Figure 4.

Figure 4

Open in a new tab

TEM images of Ru-morin@air and Ru-morin@N2 NCs.

Figure 5.

Figure 5

Open in a new tab

SAED pattern of Ru-morin@air and Ru-morin@N2 NCs.

Figure 6.

Figure 6

Open in a new tab

Histogram of Ru-morin@air and Ru-morin@N2 NCs.

FTIR Analysis

To get information about the bond vibrations of the NCs, the solid-state FTIR spectroscopy was performed. We tried to compare the bond frequencies present in the NC to that of the pure morin molecule to get a clear idea about the change, appearance, or disappearance of bond vibrations. Figure 7 represents the FTIR spectra of pure morin, Ru-morin@air, and Ru-morin@N2 NCs. On inspection of the three spectra, we found that, on NC formation, a clear change is observed in the 1612–831 cm–1 region. For Ru-morin@air, the peak at 1612 cm–1 for C=C stretching vibration present in morin was shifted to 1619 cm–1. The two peaks at 1515 and 1445 cm–1 for aromatic C=C stretching and in-plane C–C–H bending present in morin moiety completely disappeared in Ru-morin@air. The peak at 1376 cm–1 for −OH bending vibration and in-plane bending vibration of the C–O–H group present in morin molecule was shifted to 1383 cm–1 in Ru-morin@air. Two peaks of morin at 1294 and 1163 cm–1 for asymmetric stretching of Ph–O bond and aromatic C–H bending, respectively, absolutely disappeared in Ru-morin@air. Rather a new peak at 1121 cm–1 for in-plane C–H bending vibration appeared upon NC formation in open atmosphere (Ru-morin@air). Another new peak at 1867 cm–1 appeared due to metal–CO bond vibration in Ru-morin@air NC. The peak at 831 cm–1 for twisting vibration of the C–O bond was absent in the NC materials. For Ru-morin@N2, although the change in bond frequency is less prominent than that for Ru-morin@air, yet we tried to elaborate the situation. The peak at 1612 cm–1 in morin was shifted to 1625 cm–1 in the Ru-morin@N2 NCs. The peak at 1515 cm–1 in the morin moiety remained unaltered on NC formation, whereas the intensity of the peak at 1445 cm–1 was measurably lowered and a new peak at 1417 cm–1 appeared in the NC. The peak at 1294 cm–1 in morin was missing in the NC, rather a new peak at 1237 cm–1 appeared due to bending vibration of CH2 group in the NC. The peak at 1376 cm–1 disappeared and a new peak at 1321 cm–1 appeared owing to = C–H bending vibration in the NC. The peak at 1163 cm–1 in the morin was shifted to 1182 cm–1 upon NC formation. Another new peak at 989 cm–1 due to C–H bond vibration appeared in the Ru-morin@N2 NC. The peak at 831 cm–1 in morin was shifted to 836 cm–1 in the Ru-morin@N2 NC material. One new peak at 1805 cm–1 appeared in this NC owing to the metal–CO bond vibration. The results with individual band identifications are presented in Table 2. The FTIR data suggest that although there is bonding between functionalities of morin and metal, no subsequent oxidation of morin could be observed, suggesting that morin is acting as a stabilizing agent.

Figure 7.

Figure 7

Open in a new tab

FTIR spectra of pure morin, Ru-morin@air, and Ru-morin@N2 NCs.

Table 2. FTIR Spectral Data of the Pure Morin, Ru-morin@air, and Ru-morin@N2 NCs with Their Possible Functionalities.

sample peak position (cm–1) functionality
Ru-morin@N2 3440 O–H group stretching frequency13
1805 metal–CO bond frequency45
1625 C=C or C=O bond vibration45,46
1515 aromatic C=C stretching and in-plane C–C–H bending47,48
1417
1321 = C–H bending45
1237 bending vibration of CH2 group49
1182 aromatic C–H bending50
1099 C–O–C asymmetric stretching50
989 vibrational frequency for C–H bond50
836 twisting of C–O bond51
Ru-morin@air 3453 O–H group stretching frequency13
1867 metal–CO bond frequency45
1619 C=C bond vibration45,46
1383 –OH bending vibration and in-plane bending vibration of C–O–H group45
1121 in-plane C–H bending vibration52
pure morin 3405 broad, due to H-bonded O–H group stretching frequency13
1612 C=C stretching frequency45,46
1515 aromatic C=C stretching and in-plane C–C–H bending47,48
1445  
1376 –OH bending vibration and in-plane bending vibration of C–O–H group45
1294 asymmetric stretching of Ph–O bond50
1163 aromatic C-H bending50
831 twisting of C-O bond51
Open in a new tab

Powder XRD

Figure S4 represents the powder X-ray diffraction pattern of Ru-morin@air and Ru-morin@N2 NCs. No major diffraction pattern in the PXRD of either of the two materials was observed. Although the TEM image and SAED pattern of Ru-morin@air indicate the nanocrystalline nature of the material, the PXRD pattern grossly reflects its amorphous nature. This can be attributed to the experimental setup of the two characterization tools. For TEM or SAED, we generally focus on a very particular portion of the NC in its microenvironment. But for PXRD, the result is basically the average behavior of a larger portion of the material. For Ru-morin@N2, both the results are in agreement with each other and indicate the amorphous nature of the material.

DLS Measurement

From DLS analysis, the hydrodynamic radii of Ru-morin@air and Ru-morin@N2 NCs were obtained as 614 and 46 nm, respectively (Figure 8). The anomalies in the particle size compared to the TEM experiment are due to the enhanced hydrodynamic radius of the NCs in solution phase present in the colloidal solution.53 The larger increase in the hydrodynamic radius for Ru-morin@air compared to Ru-morin@N2 may be attributed to the involvement of oxygen in the atmosphere that results in the generation of oxide-type particles with a resultant increase in the hydration environment. This trend in deviation is in good agreement with the results obtained from TEM experiment.

Figure 8.

Figure 8

Open in a new tab

DLS pattern of Ru-morin@air and Ru-morin@N2 NCs.

TGA Analysis

Figure 9 describes the TGA graph of the Ru-morin@N2 NC. The plot shows a gradual weight loss of the NC with the increase of temperature. But it is only 14% from the ambient temperature to 100 °C, which may be due to the presence of polyphenol moiety, which degrades upon heating. Although a significant mass loss was observed after 200 °C, as our reaction is carried out at ∼100 °C, we can say that up to this temperature, the catalyst is stable enough and is able to catalyze the reaction successfully.

Figure 9.

Figure 9

Open in a new tab

TGA graph for Ru-morin@N2 NC.

XPS Data

The narrow scan XPS images of Ru 3d and C 1s of the two NCs are plotted in Figure 10. In spite of very close proximity of Ru 3d and C 1s binding energy, Ru 3d5/2 remains outside from that of the C 1s region and hence both of them can be analyzed simultaneously in the presence of one another. From the figure, it is clear that in both of the NCs, ruthenium is present in the form of RuCl3 and RuO3 although the atomic percentages are different. The table associated with Figure 10 reflects the atomic percentages of RuCl3 and RuO3 present in the two NCs. The lower atomic percentage of RuO3 for Ru-morin@N2 NC is quite obvious as the material is prepared in inert atmosphere. The participation of morin toward the formation of NCs was also varied upon change in the preparation environment. This was confirmed from the variation of atomic percentage of sp3 carbon, sp2 carbon, C=O, −O–C=O, and C–O–C carbons, as reflected in the table of Figure 10.

Figure 10.

Figure 10

Open in a new tab

XPS images of Ru-morin@air and Ru-morin@N2 NCs.

ICP-OES Analysis

From the ICP-OES technique, the amount of ruthenium in the catalyst was found to be 1.97 × 10–3 mol %. After the first run, the catalyst was regenerated from the reaction mixture, which was further analyzed for the amount of Ru that could have been leached from the catalyst during the reaction. It was found that only 1.28% of Ru has leached from the catalyst after the first cycle. Therefore, there was a fair possibility of recyclability of the catalyst, which was further confirmed by actually recycling it four times. The experiment is described below.

Catalytic Activity of the Ru-Based NCs

After the synthesis and thorough characterization, the reactivity of the NC was examined for the hydrogenation of nitroarenes to furnish aniline derivatives. We commenced our study by performing a series of experiments to screen the catalysts using nitrobenzene (1a) as the model substrate and sodium borohydride as the reducing agent (Table 3). During our preliminary experiments for the screening of the catalysts, Ru-morin NC formed under nitrogen atmosphere (Ru-morin@N2) produced better product yields than Ru-morin@air (entries 1 and 2, Table 3). This is due to the fact that the NC entitled as Ru-morin@N2 has a smaller particle size as well as a larger surface area (24.11 m2/g) than Ru-morin@air, which help to speed up the reaction rate through the binding of increasingly more reactant molecules over the surface of the NC. Besides, it was interesting to find that the newly synthesized NC (Ru-morin@N2) is to some extent more reactive than the homogeneous RuCl3 catalyst (entry 3, Table 3). Moreover, reduction reaction using only 6 mg of pristine morin as the active catalyst gave back the substrate 1a after 3 h (entry 4, Table 3). This signifies the inactive nature of morin in this reaction.

Table 3. Screening of the Catalysts for the Nitrobenzene Reduction Using NaBH4a.

entry catalyst time (h) yieldb (%)
1 Ru-morin@air 1.5 86
2 Ru-morin@N2 1.5 91
3 RuCl3·xH2O 1.5 87
4c morin 3  
Open in a new tab
a

Condition: PhNO2 (0.1 mmol), catalyst (1.97 × 10–3 mol % of Ru), NaBH4 (0.5 mmol), water (1 mL), 100 °C, time.

b

Isolated yield.

c

6 mg of catalyst.

After screening of the catalyst, Ru-morin@N2 NC was employed to optimize the reaction conditions (Table 4). The reaction did not take place without any catalyst that ensures the principal role of the ruthenium NC in this reduction reaction (entry 1, Table 4). Several solvents, including ethanol, water–ethanol mixture (1:1), toluene, DMF, water, etc. (entries 2–6, Table 4), were screened, but except water, rest of them showed a detrimental effect on the product yield. The reactions were found to proceed satisfactorily under refluxing conditions (entries 6–8, Table 4). Besides, 6 mg of Ru-morin@N2 NC (1.97 × 10–3 mol % of Ru) was found the best for this reduction reaction (entries 6, 11–12, Table 4).

Table 4. Screening of Reaction Parameters for Nitrobenzene Reduction Using Ru-morin@N2a.

entry cat. (mg) solvent T (°C) t (h) yield (%)b
1   water 100 1.5  
2 6 EtOH 65 1.5 78
3 6 H2O/EtOH (1:1) 70 1.5 82
4 6 DMF 120 1.5 60
5 6 toluene 110 1.5 <5
6 6 water 100 1.5 91
7 6 water 50 1.5 54
8 6 water rt 1.5 25
9 6 water 100 1 80
10 6 water 100 2 92
11 2.5 water 100 1.5 81
12 12 water 100 1.5 >92
Open in a new tab
a

Condition: PhNO2 (0.1 mmol), NaBH4 (0.5 mmol), Ru-morin@N2, solvent (1.0 mL).

b

Isolated yield.

Similar to that of the catalyst, reducing agent is also another important parameter for this reaction. The reaction did not furnish any product without any reducing agent (entry 1, Table 5). Several types of reducing agents were examined for this reaction (Table 5). Among them, SnCl2, d-glucose, d-galactose, ascorbic acid, formic acid, and disodium tartrate remained unsuccessful to furnish any desired products (entries 2–7, Table 5). It was found that hydrazine monohydrate produced only around 60% yield, while sodium borohydride gives 91% yield under the same condition (entries 8 and 9, Table 5). The amount of NaBH4 was also screened (entries 9–11, Table 5), and the best result was obtained in the presence of 0.5 mmol NaBH4 using 6 mg of Ru-morin@N2 (1.97 × 10–3 mol % of Ru) in water as the green solvent after 1.5 h of stirring under refluxing conditions.

Table 5. Screening of Reaction Parameters for Nitrobenzene Reduction Using Ru-morin@N2a.

entry reducer yield (%)b
1    
2 SnCl2  
3 d-glucose  
4 d-galactose  
5 ascorbic acid  
6 formic acid  
7 disodium tartrate  
8 hydrazine monohydrate 58
9 NaBH4 91
10c NaBH4 79
11d NaBH4 90
Open in a new tab
a

Condition: PhNO2 (0.1 mmol), Ru-morin@N2 (6 mg, 1.97 × 10–3 mol % of Ru), reducing agent (0.5 mmol), water (1.0 mL), 100 °C, 1.5 h.

b

Isolated yield.

c

0.25 mmol NaBH4.

d

1.0 mmol NaBH4.

After the attainment of the best reaction conditions, scope and efficiency of this methodology were further extended for the reduction of several substituted nitrobenzenes. Except aniline products, no side products were formed during the course of this reduction reaction, which undoubtably signifies the selectivity of our newly synthesized methodology. The results are given in Table 6. Substrates having the phenyl ring substituted by electron-donating groups as well as electron-withdrawing groups bestowed good to best product yields using our optimized reaction conditions. Reduction of 1-methyl-3-nitrobenzene and 1-methoxy-2-nitrobenzene produced their corresponding amino products with 93 and 91% yields (entries 2 and 3, Table 6). The nitro group of 1-bromo-3-nitrobenzene was successfully reduced to furnish the amino product 3-bromoaniline with 89% yield (entry 4, Table 6). Our optimized reaction condition was found to be very selective toward the nitro group, keeping the −CN group unaffected in the case of 4-nitrobenzonitrile (entry 5, Table 6).

Table 6. Synthesis of Aniline Derivativesa,b,c,d.

graphic file with name ao9b02770_0010.jpg

Open in a new tab
a

Conditions: PhNO2 (0.1 mmol), Ru-morin@N2 (6 mg, 1.97 × 10–3 mol % of Ru), NaBH4 (0.5 mmol), water (1.0 mL), 100 °C, time.

b

NMR spectra are given in the Supporting Information (Figures S5–S9).

c

Isolated yields.

d

TOF = TON/time [TON = moles of substrate converted per mole of active site].

Recyclability

Capability of recycle and reuse are the principal advantages of a heterogeneous catalyst. To examine the recycling efficiency of the NCs, reduction reaction was performed using nitrobenzene as the model substrate. The recyclability chart of the NCs is presented in Figure 11. Further, the stability of the reused catalyst was examined by FTIR analysis (Figure 12) (Table 7), and from this spectrum and the table, it is quite clear that the newly synthesized Ru-morin@N2 NC is significantly stable up to four cycles without a considerable loss in its activity.

Figure 11.

Figure 11

Open in a new tab

Recycling efficiency of Ru-morin@N2 NC.

Figure 12.

Figure 12

Open in a new tab

FTIR of the reused Ru-morin@N2 NC.

Table 7. FTIR Spectral Data of Ru-morin@N2 NCs and After Four Catalyst Cycles.

initial peak position (cm–1) peak position (cm–1) after reuse
3440 3400
1805 1831
1625 1643
1515 1565, 1480
1417 1416
1321 1345, 1281, 1260
1237
1182 1131
1099 1085
989 1003, 944
836 825
Open in a new tab

The importance and efficiency of our methodology were compared to the literature reports.

Conclusion

In conclusion, a newly designed ruthenium-based nanocatalyst has been synthesized through a mild and eco-friendly methodology under inert atmosphere. Interestingly, the nanocatalyst provides excellent catalytic activity for the synthesis of several substituted anilines using water as green solvent. Our newly generated methodology showcases a number of advantages: (a) significantly lower time of reaction; (b) use of water as green solvent; (c) scope of wide functionalization; (d) small particle size of the NC; (e) ease of catalyst as well as product separation; (f) excellent turnover frequency; and (g) hassle-free technique for the synthesis of the NC. We have summarized a comparison of our work with the previously reported reduction methodologies of similar aromatic nitro compounds using Ru-based catalyst in Table 8. The all round advantage of water-based catalyst generation and reaction conditions together with a wide suitable ratio of reducing agent to starting material, product yield, and catalyst reusability make the method fairly attractive.

Table 8. Comparison Table for Previously Reported Method for Reduction of Nitrobenzene Using Ru-Based Catalyst with Our Method of Reduction.

starting material corresponding amine derivative catalyst solvent reducing agent(s) reducing agent: starting material reaction condition yield (%) no. of cycles ref
p-chloro nitrobenzene p-chloro aniline Ru/RGOa composite water:alcohol mixture (4:1) 3 mPa H2 pressure (as H2 source)   60 °C, 2 h in an autoclave 96 5 (11)
p-chloro nitrobenzene p-chloro aniline Ru(II)–Schiff-base catalyst water NaBH4 4:1 RTb, 24 h 92   (6)
nitrobenzene aniline SBAc-supported Ru catalyst ethanol N2H4 17:1 80 °C, 21 h, air >99   (35)
R1-NO2 + R2-OH R1-NH-R2 [Ru (p-cymene) Cl2}2] alcohol     DPPBd, K2CO3, 130 °C, Ar atm., 12 h 95   (54)
p-substituted nitrobenzene p-substituted aniline [Ru(bpye)2(MeCN)2] methanol N2H4 17:1 hν > 300 nm, 5 h 99   (55)
nitrobenzene aniline Ru-CMKf–3 nanoconjugate water N2H4 4:1 1200 rpm, 30 °C, 1 h     (56)
nitro derivative of substituted benzene + (R′ CH2CH2)4 NBr corresponding substituted amine derivative RuCl2(PPh3)3 dioxane SnCl2·2H2O 1:2 18 °C, 20 h, Ar atm. 61   (57)
substituted nitrobenzene substituted aniline Ru/C nanoparticle tetrahydrofuran ethanol (as hydrogen source) 3:1 to 15:1 KOH, toluene, 120 °C, 12 h, 1 atm H2 99 5 (58)
Ph-NO2 + PhCH2OH N-substituted amine Ru(acacg)3 chlorobenzene     DPPEh, KHCO3, PhCl, 150 °C, 16 h, Ar atm. 94   (59)
nitrobenzene aniline ionic liquid-containing Ru catalyst toluene (CH3)2 NHBH3 (as hydrogen source) 6:1 RTb, 2–6 h 99 4 (60)
nitrobenzene N-substituted amine Ru catalyst toluene     KOtAmyl, benzyl alcohol, 120 °C, 7 h 95   (61)
p-substituted nitrobenzene p-substituted aniline and corresponding hydroxyl amine polystyrene-conjugated Ru catalyst chloroform or ethanol N2H4 2.3:1 to 4.5:1 RTb, 30–90 min 98 (corresponding hydroxyl amine)   (12)
nitrobenzene aniline Ru-morin catalyst water NaBH4 2:1 to 20:1 100 rpm, 100 °C, 2 h 91% 4 this work
Open in a new tab
a

Reduced graphene oxide.

b

Room temperature.

c

Santa Barbara amorphous.

d

1,2-Bis(diphenylphosphanyl)benzene.

e

Bipyridine.

f

Ordered mesoporous carbon.

g

Acetylacetone.

h

1,2-Bis(diphenylphosphino)ethane.

Experimental Section

Materials

Ruthenium(III) chloride hydrate (RuCl3·xH2O, MW: 207.43), morin hydrate [(2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one)], nitrobenzene (≥99.0%), and CDCl3 were obtained from Sigma-Aldrich. All other reagents required for this study were of AR grade and used as obtained. All of the solvents used were distilled and dried before the actual use. Triple-distilled water was used throughout the experiment.

Apparatus

Absorption spectral data were acquired using PerkinElmer Lambda 25 UV–Vis spectrophotometer. Nitrogen adsorption–desorption isotherms were analyzed at liquid nitrogen temperature (77 K) using a Quantachrome surface area analyzer. The specific surface area and pore diameter were calculated using the Brunauer–Emmett–Teller (BET) method. Transmission electron microscopy (TEM) images were obtained using a Jeol JEM 2100 HR with electron energy loss spectroscopy (EELS). Fourier transform infrared (FTIR) spectra of the samples were recorded in the range 400–4000 cm–1 on a PerkinElmer FT-IR 783 spectrophotometer having a resolution of 1 cm–1 and PerkinElmer FT-IR Spectrum Two Spectrophotometer having a resolution of 0.5 cm–1 using KBr pellets. A Mettler Toledo digital balance correct up to fourth decimal place was used for measuring the weights. A centrifuge machine Remi Elektrotechnik Ltd. R-4C was used to separate the supernatant solution of the nanoparticle. X-ray diffraction (XRD) was measured using X-PERT-PRO Panalytical diffractometer to confirm the actual phase of the prepared material. X-ray photoelectron spectroscopy (XPS) measurement was carried out using a Thermo Scientific Escalab 250 Xi system. The hydrodynamic radii of the NCs were estimated using Malvern Zetasizer Nano S, model ZEN 1600 dynamic light scattering (DLS) instrument. The thermogravimetric analysis of the NCs was conducted using Diamond TG/DTA Thermogravimetric/Differential Thermal Analyzer of PerkinElmer Instruments in the temperature range of 28–439 °C. A digital Mettler Toledo Seven Compact pH/ion meter was used to measure and adjust the pH of the solutions. The mol % of ruthenium present in the NCs was estimated using ICP-OES instrument (ICAP duo 6500, Thermo Fisher Scientific; RF power, 1150 W; flush pump rate, 50 rpm; analysis pump rate, 50 rpm; auxiliary gas flow, 1.0 L/min, Nebulizer gas flow, 0.60 L/min; coolant gas flow, 12 L/min; and wavelength, 287.876 nm). Thin-layer chromatography (TLC) analysis was performed on TLC silica gel 60 F254. The products were purified using silica gel (60–120 mesh) column chromatography. NMR spectra were recorded on a 300 and 400 MHz NMR instrument using CDCl3 as solvents. The 1H chemical shifts are reported in ppm relative to TMS.

Synthesis of Ruthenium NCs at Open Atmosphere (Ru-morin@air)

Initially, 5 mL of 10 mM aqueous solution of RuCl3 was prepared at ∼18 °C. Then, it was added to 5 mL of 10 mM ethanolic solution of morin. Thereafter, the resulting solution was kept undisturbed overnight after adjusting the pH to ∼12 using NaOH solution. The solution was then centrifuged at 2000 rpm for 10 min, and the supernatant solution was discarded. The residue was washed several times with a water:EtOH (1:1) mixture until the washing was colorless. Finally, the solid NC, designated as Ru-morin@air, was dried and taken for characterization and application.

Synthesis of Ruthenium NCs under N2 Atmosphere (Ru-morin@N2)

The synthesis procedure of this case is similar to that of Ru-morin@air. The only difference lies in the atmospheric condition of synthesis. Here, preparation of all of the solutions and the total synthesis procedure were carried out in a glovebox under N2 atmosphere. As in the previous case, the NC was washed several times with a water:EtOH (1:1) mixture and finally dried before taking out of the N2 atmosphere and designated as Ru-morin@N2.

Acknowledgments

P.S. express sincere thanks to University Grants Commission (UGC) (Ref no. of PS 20/12/2015(ii)EU-V dated 24.08.2016) for providing necessary fellowship. The authors also express their sincere gratitude to Nayan Ranjan Saha, Department of Chemical Technology, University of Calcutta, India, for measuring the XRD analysis. They are also thankful to Dipak Chandra Konar, Technical Officer-I, Chemistry, Bose Institute, Main Campus, for measuring DLS of their samples. They would like to express their sincere gratitude to Prof. Susanta Lahiri, Chemical Science Division, Saha Institution for Nuclear Physics, India, and his fellow Nabanita Naskar for measuring ICP of our sample to determine the mol percentage of the NC. They are thankful to Dr. Dipankar Chattopadhyay, Department of Polymer Science and Technology, University of Calcutta, India, for obtaining FTIR spectra of the reused catalyst.

Supporting Information Available

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsomega.9b02770.

  • UV interaction between morin and ruthenium at pH 5, 7, and 9; PXRD pattern of Ru-NCs; 1H and 13C NMR spectra of the synthesized products; and related references (PDF)

The authors declare no competing financial interest.

Supplementary Material

ao9b02770_si_001.pdf (519.3KB, pdf)

References

  1. Takale B. S.; Bao M.; Yamamoto Y.; Almansour A. I.; Arumugam N.; Kumar R. S. Applications of Metal Nanopore Catalysts in Organic Synthesis. Syn. Lett. 2015, 26, 2355–2380. 10.1055/s-0034-1380867. [DOI] [Google Scholar]
  2. Hudson R.; Feng Y.; Varma R. S.; Moores A. Bare magnetic nanoparticles: sustainable synthesis and applications in catalytic organic transformations. Green Chem. 2014, 16, 4493–4505. 10.1039/C4GC00418C. [DOI] [Google Scholar]
  3. Zaera F. Nanostructured materials for applications in heterogeneous catalysis. Chem. Soc. Rev. 2013, 42, 2746–2762. 10.1039/C2CS35261C. [DOI] [PubMed] [Google Scholar]
  4. Halder M.; Islam M. M.; Ansari Z.; Ahammed S.; Sen K.; Islam S. M. Biogenic nano-CuO-catalyzed facile C–N cross-coupling reactions: scope and mechanism. ACS Sustainable Chem. Eng. 2017, 5, 648–657. 10.1021/acssuschemeng.6b02013. [DOI] [Google Scholar]
  5. Halder M.; Islam M. M.; Singh P.; Roy A. S.; Islam S. M.; Sen K. Sustainable Generation of Ni(OH)2 Nanoparticles for the Green Synthesis of 5-Substituted 1 H-Tetrazoles: A Competent Turn on Fluorescence Sensing of H2O2. ACS Omega 2018, 3, 8169–8180. 10.1021/acsomega.8b01081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jia W.-G.; Zhang H.; Zhang T.; Xie D.; Ling S.; Sheng E.-H. Half-sandwich ruthenium complexes with Schiff-base ligands: Syntheses, characterization, and catalytic activities for the reduction of nitroarenes. Organometallics 2016, 35, 503–512. 10.1021/acs.organomet.5b00933. [DOI] [Google Scholar]
  7. Tiruwa R. A review on nanoparticles-preparation and evaluation parameters. Indian J. Pharm. Biol. Res. 2015, 4, 27–31. 10.30750/ijpbr.4.2.4. [DOI] [Google Scholar]
  8. Ealias A. M.; Saravanakumar M. P. A review on the classification, characterization, synthesis of nanoparticles and their application. IOP Conf. Ser.: Mater. Sci. Eng. 2017, 263, 32019–32033. 10.1088/1757-899X/263/3/032019. [DOI] [Google Scholar]
  9. Lara P.; Philippot K.; Chaudret B. Organometallic ruthenium nanoparticles: a comparative study of the influence of the stabilizer on their characteristics and reactivity. Chem. Cat. Chem. 2012, 5, 28–45. 10.1002/cctc.201200666. [DOI] [Google Scholar]
  10. Salas G.; Campbell P. S.; Santini C. C.; Philippot K.; Gomes M. F. C.; Pádua A. A. H. Ligand effect on the catalytic activity of ruthenium nanoparticles in ionic liquids. Dalton Trans. 2012, 41, 13919–13926. 10.1039/c2dt31644g. [DOI] [PubMed] [Google Scholar]
  11. Fan G.-Y.; Huang W.-J. Synthesis of ruthenium/reduced graphene oxide composites andapplication for the selective hydrogenation of halonitroaromatics. Chin. Chem. Lett. 2014, 25, 359–363. 10.1016/j.cclet.2013.11.044. [DOI] [Google Scholar]
  12. Tyler J. H.; Nazari S. H.; Patterson R. H.; Udumula V.; Smith S. J.; Michaelis D. J. Synthesis of N-aryl and N-heteroaryl hydroxylamines via partial reduction of nitroarenes with soluble nanoparticle catalysts. Tetrahedron Lett. 2017, 58, 82–86. 10.1016/j.tetlet.2016.11.105. [DOI] [Google Scholar]
  13. Kannan S. K.; Sundrarajan M. Green synthesis of ruthenium oxide nanoparticles: Characterization and its antibacterial activity. Adv. Powder Technol. 2015, 26, 1505–1511. 10.1016/j.apt.2015.08.009. [DOI] [Google Scholar]
  14. Ismail E.; Khamlich S.; Dhlamini M.; Maaza M. Green biosynthesis of ruthenium oxide nanoparticles on nickel foam as electrode material for supercapacitor applications. RSC Adv. 2016, 6, 86843–86850. 10.1039/C6RA17996G. [DOI] [Google Scholar]
  15. Zhou Y.; Xu M.; Liu Y.; Bai Y.; Deng Y.; Liu J.; Chen L. Green synthesis of Se/Ru alloy nanoparticles using gallic acid and evaluation of theiranti-invasive effects in HeLa cells. Colloids Surf., B 2016, 144, 118–124. 10.1016/j.colsurfb.2016.04.004. [DOI] [PubMed] [Google Scholar]
  16. Ni X.; Zhang B.; Li C.; Pang M.; Su D.; Williams C. T.; Liang C. Microwave-assisted green synthesis of uniform Ru nanoparticles supported on non-functional carbon nanotubes for cinnamaldehyde hydrogenation. Catal. Commun. 2012, 24, 65–69. 10.1016/j.catcom.2012.03.035. [DOI] [Google Scholar]
  17. Zhao J.; Hu W.; Li H.; Ji M.; Zhao C.; Wang Z.; Hu H. One-step green synthesis of a ruthenium/graphene composite as a highly efficient catalyst. RSC Adv. 2015, 5, 7679–7686. 10.1039/C4RA11397G. [DOI] [Google Scholar]
  18. García-Peña N. G.; Redón R.; Herrera-Gomez A.; Fernández-Osorio A. L.; Bravo-Sanchez M.; Gomez-Sosa G. Solventless synthesis of ruthenium nanoparticles. Appl. Surf. Sci. 2015, 340, 25–34. 10.1016/j.apsusc.2015.02.186. [DOI] [Google Scholar]
  19. Taşçı E.; Akbayrak S.; Özkar S. Ruthenium (0) nanoparticles supported on silica coated Fe3O4 as magnetically separable catalysts for hydrolytic dehydrogenation of ammonia borane. Int. J. Hydrogen Energy 2018, 43, 15124–15134. 10.1016/j.ijhydene.2018.06.058. [DOI] [Google Scholar]
  20. Jagadeesh R. V.; Surkus A.-E.; Junge H.; Pohl M.-M.; Radnik J.; Rabeah J.; Huan H.; Schünemann V.; Brückner A.; Beller M. Nanoscale Fe2O3-based catalysts for selective hydrogenation of nitroarenes to anilines. Science 2013, 342, 1073–1076. 10.1126/science.1242005. [DOI] [PubMed] [Google Scholar]
  21. Wei H.; Liu X.; Wang A.; Zhang L.; Qiao B.; Yang X.; Huang Y.; Miao S.; Liu J.; Zhang T. FeOx-supported platinum single-atom and pseudo-single-atom catalysts for chemoselective hydrogenation of functionalized nitroarenes. Nat. Commun. 2014, 5, 5634–5641. 10.1038/ncomms6634. [DOI] [PubMed] [Google Scholar]
  22. Tafesh A. M.; Weiguny J. A review of the selective catalytic reduction of aromatic nitro compounds into aromatic amines, isocyanates, carbamates, and ureas using CO. Chem. Rev. 1996, 96, 2035–2052. 10.1021/cr950083f. [DOI] [PubMed] [Google Scholar]
  23. Radl S.; Koynov A.; Tryggvason G.; Khinast J. G. DNS-based prediction of the selectivity of fast multiphase reactions: Hydrogenation of nitroarenes. Chem. Eng. Sci. 2008, 63, 3279–3291. 10.1016/j.ces.2008.03.025. [DOI] [Google Scholar]
  24. Lawrence S. A.Amines: Synthesis, Properties and Applications; Cambridge University Press: Cambridge, 2004. [Google Scholar]
  25. Travis S.; Rappoport Z.. The Chemistry of Anilines; John Wiley & Sons, Ltd.: Chichester, 2007. [Google Scholar]
  26. Rai R. K.; Mahata A.; Mukhopadhyay S.; Gupta S.; Li P.-Z.; Nguyen K. T.; Zhao Y.; Pathak B.; Singh S. K. Room-temperature chemoselective reduction of nitro groups using non-noble metal nanocatalysts in water. Inorg. Chem. 2014, 53, 2904–2909. 10.1021/ic402674z. [DOI] [PubMed] [Google Scholar]
  27. Liu J.; Cui J.; Vilela F.; He J.; Zeller M.; Hunter A. D.; Xu Z. In situ production of silver nanoparticles on an aldehyde-equipped conjugated porous polymer and subsequent heterogeneous reduction of aromatic nitro groups at room temperature. Chem. Commun. 2015, 51, 12197–12200. 10.1039/C5CC04476F. [DOI] [PubMed] [Google Scholar]
  28. Jia W.-G.; Dai Y.-C.; Zhang H.-N.; Lu X.; Sheng E.-H. Synthesis and characterization of gold complexes with pyridine-based SNS ligands and as homogeneous catalyst for reduction of 4-nitrophenol. RSC Adv. 2015, 5, 29491–29496. 10.1039/C5RA01749A. [DOI] [Google Scholar]
  29. Zhao Z.; Yang H.; Li Y.; Guo X. Cobalt-modified molybdenum carbide as an efficient catalyst for chemoselective reduction of aromatic nitro compounds. Green Chem. 2014, 16, 1274–1281. 10.1039/C3GC42049C. [DOI] [Google Scholar]
  30. Yang X.-J.; Chen B.; Zheng L.-Q.; Wu L.-Z.; Tung C.-H. Highly efficient and selective photocatalytic hydrogenation of functionalized nitrobenzenes. Green Chem. 2014, 16, 1082–1086. 10.1039/C3GC42042F. [DOI] [Google Scholar]
  31. Liu X.; Ye S.; Li H.-Q.; Liu Y.-M.; Cao Y.; Fan K.-N. Mild, selective and switchable transfer reduction of nitroarenes catalyzed by supported gold nanoparticles. Catal. Sci. Technol. 2013, 3, 3200–3206. 10.1039/c3cy00533j. [DOI] [Google Scholar]
  32. de Noronha R. G.; Romão C. C.; Fernandes A. C. Highly chemo-and regioselective reduction of aromatic nitro compounds using the system silane/oxo-rhenium complexes. J. Org. Chem. 2009, 74, 6960–6964. 10.1021/jo9008657. [DOI] [PubMed] [Google Scholar]
  33. Jansat S.; Picurelli D.; Pelzer K.; Philippot K.; Gomez M.; Muller G.; Lecante P.; Chaudret B. Synthesis, characterization and catalytic reactivity of ruthenium nanoparticles stabilized by chiral N-donor ligands. New J. Chem. 2006, 30, 115–122. 10.1039/B509378C. [DOI] [Google Scholar]
  34. Tomkins P.; Gebauer-Henke E.; Leitner W.; Müller T. E. Concurrent hydrogenation of aromatic and nitro groups over carbon-supported ruthenium catalysts. ACS Catal. 2015, 5, 203–209. 10.1021/cs501122h. [DOI] [Google Scholar]
  35. Carrillo A. I.; Stamplecoskie K. G.; Marin M. L.; Scaiano J. C. ‘From the mole to the molecule’: ruthenium catalyzed nitroarene reduction studied with ‘bench’, high-throughput and single molecule fluorescence techniques. Catal. Sci. Technol. 2014, 4, 1989–1996. 10.1039/C4CY00018H. [DOI] [Google Scholar]
  36. Indra A.; Maity N.; Maity P.; Bhaduri S.; Lahiri G. K. Control of chemoselectivity in hydrogenations of substituted nitro-and cyano-aromatics by cluster-derived ruthenium nanocatalysts. J. Catal. 2011, 284, 176–183. 10.1016/j.jcat.2011.09.020. [DOI] [Google Scholar]
  37. Panhwar Q. K.; Memon S. Synthesis of Cr (III)-morin complex: Characterization and antioxidant study. Sci. World J. 2014, 2014, 1–9. 10.1155/2014/845208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Ghatak S. K.; Dey D.; Sen S.; Sen K. Aromatic amino acids in high selectivity bismuth (III) recognition. Analyst 2013, 138, 2308–2314. 10.1039/c3an36842d. [DOI] [PubMed] [Google Scholar]
  39. Thanh N. T. K.; Maclean N.; Mahiddine S. Mechanisms of nucleation and growth of nanoparticles in solution. Chem. Rev. 2014, 114, 7610–7630. 10.1021/cr400544s. [DOI] [PubMed] [Google Scholar]
  40. Sudarsanam P.; Peeters E.; Makshina V. E.; Parvulescu V. I.; Sels B. F. Advances in porous and nanoscale catalysts for viable biomass conversion. Chem. Soc. Rev. 2019, 48, 2366–2421. 10.1039/C8CS00452H. [DOI] [PubMed] [Google Scholar]
  41. Isaacs M. A.; Robinson N.; Barbero B.; Durndell L. J.; Manayil J. C.; Parlett C. M. A.; D’Agostino C.; Wilson K.; Lee A. F. Unravelling mass transport in hierarchically porous catalysts. J. Mater. Chem. A. 2019, 7, 11814–11825. 10.1039/C9TA01867K. [DOI] [Google Scholar]
  42. Thommes M.; Kaneko K.; Neimark A. V.; Olivier J. P.; Rodriguex-Reinoso F.; Rouquerol J.; Sing K. S. W. Physisorption of gases, with special reference to the evaluation of surface area and pore size distribution (IUPAC Technical Report). Pure Appl. Chem. 2015, 87, 1051–1069. 10.1515/pac-2014-1117. [DOI] [Google Scholar]
  43. Alp E.; Aydogan N. A comparative study: synthesis of superparamagnetic iron oxide nanoparticles in air and N2 atmosphere. Colloids Surf., A 2016, 510, 205–212. 10.1016/j.colsurfa.2016.06.033. [DOI] [Google Scholar]
  44. Stari C.; Cichetto L. Jr.; Peres C. H. M. A.; Rivera V. A. G.; Sergeenkov S.; Cardoso C. A.; Marega E.; Araújo-Moreira F. M. Comparative study on structure and magnetic properties of polycrystalline PrxY1– xBa2Cu3O7– δ prepared in oxygen and argon atmosphere. J. Alloys Compd. 2012, 528, 135–140. 10.1016/j.jallcom.2012.03.048. [DOI] [Google Scholar]
  45. Fuloria N. K.; Fuloria S.. Spectroscopy: Fundamantals and Data Interpretation; Studium Press India Pvt. Ltd., 2013. [Google Scholar]
  46. Shah M. P. Exploited application of Lactobacillus in microbial degradation and decolorization of acid orange. Int. J. 2014, 2, 160–166. 10.12691/ijebb-2-4-3. [DOI] [Google Scholar]
  47. Stammer C.; Taurins A. Infrared spectra of phenazines. Spectrochim. Acta 1963, 19, 1625–1653. 10.1016/0371-1951(63)80161-7. [DOI] [Google Scholar]
  48. Gilbert A. S. In Encyclopedia of Spectroscopy and Spectrometry. Academic Press: U.K.; 1999, pp 1035–1048. [Google Scholar]
  49. Mary Y. S.; Jojo P. J.; Alsenoy C. V.; Kaur M.; Siddegowda M. S.; Yathirajan H. S.; Nogueira H. I. S.; Cruz S. M. A. Vibrational spectroscopic (FT-IR, FT-Raman, SERS) and quantum chemical calculations of 3-(10, 10-dimethyl-anthracen-9-ylidene)-N, N, N-trimethylpropanaminiium chloride (Melitracenium chloride). Spectrochim. Acta, Part A 2014, 120, 370–380. 10.1016/j.saa.2013.10.021. [DOI] [PubMed] [Google Scholar]
  50. Logacheva N. M.; Baulin V. E.; Tsivadze A.; Pyatova E. N.; Ivanova I. S.; Velikodny Y. A.; Chernyshev V. V. Ni (II), Co (II), Cu (II), Zn (II) and Na (I) complexes of a hybrid ligand 4′-(4‴-benzo-15-crown-5)-methyloxy-2, 2′: 6′, 2 ″-terpyridine. Dalton Trans. 2009, 14, 2482–2489. 10.1039/b819805e. [DOI] [PubMed] [Google Scholar]
  51. Yadav R. A.; Dixit V.; Yogesh M.; Santhosh C. Raman and IR spectral and DFT based vibrational and electronic characterization of isolated and zwitterionic forms of L-tyrosin. Pharm. Anal. Acta 2015, 6, 1–18. 10.4172/2153-2435.1000439. [DOI] [Google Scholar]
  52. Husin M. R.; Arsad A.; Suradi S. S.; Alothman O.; Ngadi N.; Kamaruddin M. J. Fourier transforms infrared spectroscopy and X-ray diffraction investigation of recycled polypropylene/polyaniline blends. Chem. Eng. Trans. 2017, 56, 1015–1020. 10.3303/CET1756170. [DOI] [Google Scholar]
  53. Ansari Z.; Saha A.; Singha S. S.; Sen K. Phytomediated generation of Ag, CuO and Ag-Cu nanoparticles for dimethoate sensing. J. Photochem. Photobiol., A 2018, 367, 200–211. 10.1016/j.jphotochem.2018.08.026. [DOI] [Google Scholar]
  54. Cui X.; Zhang Y.; Shi F.; Deng Y. Ruthenium-catalyzed nitro and nitrile compounds coupling with alcohols: Alternative route for N-substituted amine synthesis. Chem. – Eur. J. 2011, 17, 2587–2591. 10.1002/chem.201003095. [DOI] [PubMed] [Google Scholar]
  55. Hirao T.; Shiori J.; Okahata N. Ruthenium–bipyridine complex-catalyzed photo-induced reduction of nitrobenzenes with hydrazine. Bull. Chem. Soc. Jpn. 2004, 77, 1763–1764. 10.1246/bcsj.77.1763. [DOI] [Google Scholar]
  56. Hu J.; Ding Y.; Zhang H.; Wu P.; Li X. Highly effective Ru/CMK-3 catalyst for selective reduction of nitrobenzene derivatives with H2O as solvent at near ambient temperature. RSC Adv. 2016, 6, 3235–3242. 10.1039/C5RA24362A. [DOI] [Google Scholar]
  57. Cho C. S.; Kim T. K.; Choi H.-J.; Kim T.-J.; Shim S. C. Ruthenium-catalyzed consecutive reduction and cyclization of nitroarenes with tetraalkylammonium bromides leading to quinolines. Bull. Korean Chem. Soc. 2002, 23, 541–542. 10.5012/bkcs.2002.23.4.541. [DOI] [Google Scholar]
  58. Kim J. H.; Park J. H.; Chung Y. K.; Park K. H. Ruthenium nanoparticle-catalyzed, controlled and chemoselective hydrogenation of nitroarenes using ethanol as a hydrogen source. Adv. Synth. Catal. 2012, 354, 2412–2418. 10.1002/adsc.201200356. [DOI] [Google Scholar]
  59. Liu Y.; Chen W.; Feng C.; Deng G. Ruthenium-catalyzed one-pot aromatic secondary amine formation from nitroarenes and alcohols. Chem. Asian J. 2011, 6, 1142–1146. 10.1002/asia.201000945. [DOI] [PubMed] [Google Scholar]
  60. Patil N. M.; Sasaki T.; Bhanage B. M. Immobilized ruthenium metal-containing ionic liquid-catalyzed dehydrogenation of dimethylamine borane complex for the reduction of olefins and nitroarenes. RSC Adv. 2016, 6, 52347–52352. 10.1039/C6RA09785E. [DOI] [Google Scholar]
  61. Suntrup L.; Hohloch S.; Sarkar B. Expanding the scope of chelating triazolylidenes: mesoionic carbenes from the 1, 5-“Click”-regioisomer and catalytic synthesis of secondary amines from nitroarenes. Chem. – Eur. J. 2016, 22, 18009–180018. 10.1002/chem.201603901. [DOI] [PubMed] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

ao9b02770_si_001.pdf (519.3KB, pdf)

Articles from ACS Omega are provided here courtesy of American Chemical Society

RESOURCES