Abstract
Objective:
To assess whether a counselor-initiated (CI) adaptation of the Look AHEAD Intensive Lifestyle Intervention (ILI) in a military setting was cost-effective relative to a self-paced (SP) adaptation.
Methods:
We performed cost-effectiveness analysis from a payer perspective alongside a 2014–2017 randomized behavioral weight loss trial among 248 active duty military personnel stationed at a US Air Force Base in Texas. We calculated incremental cost-effectiveness ratios (ICERs) for weight loss, reductions in waist circumference, and quality-adjusted life years (QALYs).
Results:
After 12 months, the CI adaptation cost more per participant compared to the SP adaptation ($1,081 vs. $120), but achieved greater weight loss (1.86kg vs. 0.06kg), reductions in waist circumference (1.85cm vs. 0.48cm), and more QALYs (0.871 vs. 0.856). The ICER for CI relative to the SP adaptation was $61,268 per additional QALY. At willingness-to-pay thresholds of $50,000 and $100,000 per QALY the CI adaptation was 45 and 49% likely to be cost-effective.
Conclusions:
The CI delivery of the Look AHEAD ILI may offer a cost-effective approach to tackle excess weight in the US military.
Keywords: Weight loss, Cost Effectiveness, Intervention, Behavioral Strategies, Adults
Introduction
Evidence of the effectiveness of a health promotion intervention alone is often insufficient for informed decision making. Public health resources are limited and decision makers are required to set priorities when allocating scarce resources. Evidence derived from economic evaluations such as cost-effectiveness analysis of health promotion interventions can assist decision makers in setting budget priorities. In addition, evidence-based health promotion interventions, including weight loss and weight management interventions, should be tailored to accommodate the target population’s specific context and needs.(1, 2) It is valuable to examine the cost-effectiveness of a tailored intervention for several reasons: there are differences in the context of interventions, needs vary from one population to another, and unique changes made to an intervention may affect both the costs and effectiveness.(3)
The US military represents one important population that could benefit from tailored weight loss and weight management interventions. In 2016, the US military employed over 3.5 million people, including over 1.2 million US Department of Defense (DoD) active-duty personnel in each of its services branches: Army (471,271), Navy (320,101), Air Force (313,723), and Marine Corps (183,501).(4) Body mass index (BMI), an individual’s weight in kilograms divided by the squared height in meters, can be used to categorize individuals into weight categories. Approximately 51.0% of active-duty service members are classified as having overweight (BMI ≥25 to ≤ 29.9 kg/m2) compared to 31.6% of the general US adult population, and 14.7% are classified as having obesity (BMI ≥ 30 kg/m2) compared to 39.6% of the US population.(5–7) Excess weight and inadequate fitness among active-duty personnel are associated with higher risk of incident lower extremity musculoskeletal injury/disorder(8) and higher absenteeism rates as well as substantial costs for the DoD, including increased medical care and the cost of recruiting and training replacements for individuals discharged due to fitness test failure.(9) Dall et al.(9) estimated that 658,000 full time equivalent work days are lost due to absenteeism associated with active-duty personnel with overweight or obesity, at an annual cost of $103 million for the DoD. In addition, medical care costs associated with excess weight and obesity for active-duty personnel and their dependents, as well as military retirees and their dependents, exceeds $1 billion annually.(9) The Accession Medical Standards Analysis and Research Activity estimates that the cost of recruiting, screening, and training is $75,000 per enlistee, making each fitness-related discharge expensive for the DoD.(10) Members of the armed forces must meet strict fitness standards (e.g. abdominal circumference). Failure to meet these standards can result in military discharge which also has nontrivial consequences for service members, including loss of wages, medical benefits and years of service towards pension eligibility.(11)
The Fit Blue study, a randomized, controlled, behavioral, weight loss trial for active-duty personnel, translated the Look AHEAD Intensive Lifestyle Intervention (ILI)(12) into the military setting, specifically the Lackland Air Force Base in San Antonio, Texas. The participants were predominantly (94%) Air Force personnel, with the remaining participants in the Navy, Army, and Marine Corps. In short, the Fit Blue study compared two adapted versions of the Look AHEAD intervention: a counselor-initiated (CI) and a self-paced (SP) condition. The two groups differed in the degree of intervention intensity and the amount of self-initiation required.
Given the prevalence and adverse consequences of excess weight in the US military, examining the potential value (cost versus outcomes) of weight loss and weight management interventions in this setting is important. The purpose of this study was to assess the cost-effectiveness of the CI relative to the SP adaptation of the intervention.
Methods
The Fit Blue intervention was delivered over the phone and e-mail to make it more accessible to military personnel who are frequently on brief assignments in different locations, known as Temporary Duty. Participants in the Fit Blue study were active duty military personnel stationed at Lackland Air Force Base. To be eligible for the study, participants had to be age 18 or older, have a body mass index (BMI) of 25.0 kg/m2 or greater, have computer and email access, and have at least one year of service left at the Lackland Air Force Base to minimize the likelihood for loss to follow-up at 12 months. The time-horizon for the intervention was one year with data collected at baseline, 4 and 12 months. The primary outcome variable was weight loss at 12 months. Recruitment took place from January 2014 to March 2016, and data were collected until March 2017. Participants were randomized to CI (n=124) or SP (n=124) intervention conditions. Trained lay interventionists were either military retirees or staff who had significant knowledge of military culture. All interventionists had bachelor’s or master’s degrees in diverse areas of study. During one-on-one phone sessions, interventionists provided strategies to help participants with weight loss. Self-monitoring sessions consisted of interventionist feedback via email on participants’ food and physical activity using the Lose It!TM Website and app, and weight uploaded by participants to a secure website through Body TraceTM electronic scales. Participants in both conditions could receive up to 28 phone sessions and 28 self-monitoring feedback emails. However, while CI participants received phone calls (phone sessions) and e-mails (self-monitoring feedback) regularly by interventionists, SP participants were required to request those interactions. In addition, only CI participants were able to receive meal replacements and participate in four four-week-long challenges designed to increase motivation. Participants who successfully completed a challenge received a small prize. CI participants also had access to a toolbox which included additional resources such as exercise videos and cook books. These items could be borrowed but had to be returned prior to the end of the study. Further participant characteristics and design details for the Fit Blue intervention have been previously described.(13, 14)
Model Structure
We developed a decision-tree model using TreeAge Pro 2018 (TreeAge Software Inc, Williamstown, MA) to estimate the costs and outcomes associated with the Fit Blue intervention after 12 months. The model included the possible pathways for both intervention conditions and whether there was a significant weight loss (≥5% of initial body weight lost) or not (<5% of initial body weight lost). Possible pathways also included whether CI participants had received at least 75% of possible phone sessions and self-monitoring feedback (28 of each were possible, so 42 out of 56 possible interactions) or not, whether SP participants had any interactions or not, and whether participants in both conditions returned for the 12-month data collection or not.
Model Input Data
Decision-tree model input parameters, including probabilities, were derived from the Fit Blue trial data. Total costs and per person costs were calculated and included the following for both interventions: intervention materials, shipping costs, telephone sessions and self-monitoring feedack, and incentives for participation in data collection (Table 1). CI additionally included costs of challenge prizes and meal replacements. Costs for telephone and self-monitoring sessions were calculated based on the amount of time that interventionists spent providing telephone sessions and self-monitoring feedback multiplied by the average hourly rate, including fringe benefits, paid to study interventionists. Costs for challenge prizes depended on the number of challenges participants had participated in. The cost of meal replacements was calculated based on the number of meal replacements consumed multiplied by the average cost per meal replacement. We estimated the intervention costs in both conditions from a payer perspective. Since all intervention activities happened outside of participant work time, participant time costs were not considered. Only costs related to administering the Fit Blue intervention were included. Costs for staff training, program development, and research costs were excluded. Costs are measured and reported in US dollars at 2016 price and wage levels.
Table 1 -.
Summary of Costs for participants in the CI and SP condition (in 2016 USD)
| Cost Variables | CI condition (n=124) | SP condition (n=124) | ||
|---|---|---|---|---|
| Total cost | Per person cost | Total cost | Per person cost | |
| Materials | ||||
| Scale | $ 11,780.00 | $ 95.00 | $ 11,780.00 | $ 95.00 |
| Cups and Spoons | $ 582.80 | $ 4.70 | $ 582.80 | $ 4.70 |
| Binder | $ 2,647.40 | $ 21.35 | ||
| Toolbox | $ 1,000.00 | $ 8.06 | ||
| T-Shirt | $ 559.24 | $ 4.51 | ||
| Total materials costs | $ 16,010.20 | $ 129.11 | $ 12,922.04 | $ 104.21 |
| Challenge Prizes | ||||
| T-Shirt | $ 293.15 | $ 4.51 | ||
| Shoe Laces | $ 144.00 | $ 4.00 | ||
| Blender Bottle | $ 128.00 | $ 8.00 | ||
| Reflective Bands | $ 12.00 | $ 4.00 | ||
| Total Challenge Prizes costs | $ 577.15 | Mean: $ 4.65 Range: $ 0 – $ 20.51 |
||
| Meal Replacements | ||||
| Total Meal Replacements costs | $ 37,177.98 | Mean: $ 299.82 Range: $ 0 – $ 1,600.20 |
||
| Phone and Self-monitoring Sessions | ||||
| Total Phone and Self-monitoring Sessions costs | $ 78,118.22 | Mean: $ 629.99 Range:$57.84 – $2,158.88 |
$ 193.28 | Mean: $ 1.56 Range: $ 0 – $ 67.48 |
| Data Collection Incentives | ||||
| 4 month incentive: Pedometer | $ 1,722.20 | $ 15.80 | $ 1,422.00 | $ 15.80 |
| 12 month incentive: Water Bottle | $ 380.00 | $ 4.00 | $ 308.00 | $ 4.00 |
| Total Data Collection Incentives costs | $ 2,102.20 | Mean: $16.95 Range: $ 0 – $ 19.80 |
$ 1,730.00 | Mean: $ 13.95 Range: $ 0 – $ 19.80 |
| Total One Year Costs | $ 133,985.75 | Mean: $ 1,080.53 Range: $ 186.95 – $ 2788.74 |
$ 14,845.32 | Mean: $ 119.72 Range: $ 104.21 – $ 191.49 |
Our analysis focused on three different outcome measures at 12 months: weight loss (in kilograms), reduction in waist circumference (in centimeters), and quality-adjusted life years (QALYs). QALYs were calculated for one year and were estimated based on participant responses to the Health Utility Index Mark 2 (HUI2®) questionnaire. For missing values at 12 months, we carried forward the baseline observation which is considered a conservative method for addressing missing values.(15) We conducted univariate comparisons of mean outcome measures using Student’s t-tests and chi-square for comparing proportions.
Cost-Effectiveness Analysis
We calculated three incremental cost-effectiveness ratios (ICERs), corresponding to each outcome: incremental cost per kilogram of weight loss, incremental cost per centimeter of waist circumference reduction, and incremental cost per QALY. The ICER is defined as the difference in costs divided by the difference in the effects of the two intervention adaptations.(16)
To test the sensitivity of our results to model assumptions, we conducted a series of sensitivity analyses. For the reason that another organization may want to implement the intervention with existing (more or less expensive) staff which would impact overall intervention costs, we conducted a one-way sensitivity analysis of hourly wages for intervention staff. Tied to specific job descriptions (Dietetic Technician vs. Registered Nurse), the low and high entries are based on national median (2016) hourly wages available from the Bureau of Labor Statistics and are adjusted for fringe benefits using national 2016 rates (31.5%).(17, 18) We also conducted one-way sensitivity analyses on the costs for challenge prizes ($0 – $20.51) and for meal replacements ($0 – $1,600), acknowledging the possible imprecision of the meal replacement data collected. High and low values for these parameters were based on the high and low values observed in the trial.
To capture the impact of parameter variability on our study results, we conducted probabilistic sensitivity analyses. Using a non-parametric bootstrap technique(19), the model was run 10,000 times, each time resampling the following parameters from the original Fit Blue trial data with replacement: cost of phone sessions and self-monitoring feedback time, cost of meal replacements, and outcome measures. This non-parametric method allowed us to avoid making distributional assumptions about the parameter in question.(19) Probabilistic sensitivity analyses were used to estimate 95% confidence ellipses representing the uncertainty surrounding costs and effects and to compute cost-effectiveness acceptability curves (CEACs), which plot the percentage of iterations for which CI was preferred over SP for a range of willingness-to-pay levels.
For the reporting of results we adhered to CHEERS guidelines.(20)
Results
Out of 124 CI participants, 66 (53.2%) attended at least 75% of 56 possible phone sessions and self-monitoring feedback (at least 42 interactions). Out of 124 SP participants, 8 (6.5%) requested any sessions or feedback. The probability of weight loss ≥5% of initial body weight was greater in the CI (22.6%) than in the SP condition (9.7%) (p-value = 0.0057). The probability of lost to follow-up at 12 months was 23.4% in the CI condition, and 37.9% in the SP condition (p-value = 0.0132). The CONSORT flow diagram and the detailed decision-tree model are available as supporting information (supplementary file Figures S1, S2).
Overall intervention costs differed substantially between the two conditions. The overall cost of the CI intervention was estimated at $133,986, or $1,080.53 per participant, while the overall costs of the SP intervention were estimated at $14,845, or $119.72 per participant (Table 1). Most of the difference in costs can be attributed to interventionists’ time costs, because there were a greater number of phone sessions and self-monitoring emails among CI participants. A portion of the difference can also be attributed to meal replacements which were not available to SP participants.
Introductory pay for interventionists was $21.63 per hour or $45,000 per year. Including institutional fringe benefits, the total cost of each interventionist was $28.94 per hour. The cost of meal replacements was calculated based on the number of meal replacements consumed multiplied by the average cost per meal replacement of $5.08. Participant materials differed slightly between the two conditions, resulting in slightly higher costs for CI ($129.11) compared to SP ($104.21; see Table 1).
CI participants experienced significantly better clinical outcomes compared to SP participants. Including baseline observations carried forward for missing values, the mean weight loss was 1.86 kg among CI participants compared to 0.06 kg among SP participants (p-value = 0.0004). CI participants achieved a mean reduction in waist circumference of 1.85 cm compared to 0.48 cm for those in the SP condition (p-value = 0.0240). CI participants did not achieve significantly more QALYs at 12 months; 0.87 QALYs compared to 0.85 QALYs for SP participants (p-value = 0.3879).
Results of the base-case cost-effectiveness analyses are presented in Table 2. ICER values depended on the different denominators: weight loss in kg, waist circumference reductions in cm, and QALYs. The ICERs for CI relative to SP were $533.31 per kg lost, $698.77 per cm reduction in waist circumference, and $61,267.50 per additional QALY.
Table 2 -.
Summary of costs, effects, and cost-effectiveness for CI and SP conditions.
| Outcome measure at 12 month | CI condition | SP condition | Difference | ICER Point Estimate |
|---|---|---|---|---|
| Costs per person, in 2016 USD | 1,080.53 | 119.72 | 960.81 | N.A. |
| Weight Loss, in kg | 1.857 | 0.056 | 1.802 | 533.31 |
| Reduction in Waist Circumference, in cm | 1.853 | 0.478 | 1.375 | 698.77 |
| QALY (one-year only) | 0.871 | 0.856 | 0.016 | 61,267.50 |
One-way sensitivity analysis showed that the model was relatively sensitive to interventionists’ wages and costs for meal replacements. For hourly wages and fringe ranging from $16.66 (Dietetic Technician) to $43.28 (Registered Nurse)(17, 18), the expected intervention costs ranged from $119.06 to $120.49 for the SP condition and from $813.90 to $1,392.91 for the CI condition. The ICERs for CI relative to SP ranged from $44,307 to $81,138 per additional QALY. Per person meal replacement costs ranged from $0 to $1,600. Total intervention costs ranged from $780.71 to $2,380.71 in the CI condition and remained $119.72 in the SP condition. The ICERs for CI relative to SP ranged from $42,149 to $144,175 per additional QALY. Tornado diagrams depicting the changes in ICERs based on the varied individual parameters are available as supporting information (supplementary file Figure S3).
Probabilistic sensitivity analyses conducted with non-parametric bootstrap resampling revealed uncertainties surrounding the cost-effectiveness results. The incremental cost-effectiveness scatterplots depicted in Figure 1 show the differences in mean costs and outcome measures for CI versus SP from 10,000 bootstrap replicates. These scatterplots highlight the uncertainty in cost and outcome estimates associated with CI relative to SP.(21, 22) Each dot in the graphs represents the incremental cost (y-axis) and incremental effectiveness (x-axis) of CI relative to SP for a single bootstrap iteration. The cost effectiveness acceptability curves (CEACs) were drawn from the joint distributions of incremental costs and incremental effects derived from the non-parametric bootstrap resampling. These curves highlight uncertainty in the ICER estimates by plotting the probabilities that the CI condition is cost-effective relative to the SP condition at varying levels of the willingness-to-pay or cost-effectiveness threshold.(21, 22) The weight loss CEAC indicates a 49% probability that CI is cost-effective when the willingness-to-pay threshold is set at our base case ICER ($533 per additional kg of weight loss) but this probability approaches 80% for larger willingness-to-pay thresholds (Figure 1A). The CEAC for reduction in waist circumference suggests a 51% probability that CI is cost-effective when the willingness-to-pay threshold is set at our base case ICER ($699 per additional cm of reduction in waist circumference) but this probability approaches 70% at higher willingness-to-pay thresholds (Figure 1B). At a willingness-to-pay of $50,000 per additional QALY achieved, the probability CI is cost-effective is 45%, and at a willingness to pay of $100,000 the probability rises to 49%. The probability CI is cost-effective in terms of QALYs approaches 52% at higher willingness-to-pay thresholds (Figure 1C).
Figure 1 -.
Plots of 10,000 bootstrap replicates of the incremental costs per kilogram of weight loss (A.), centimeter reduction of waist circumference (B.), and QALYs (C.) and Cost-effectiveness Acceptability Curves (CEACs) representing the proportion of simulations for which the CI intervention was preferred at a given willingness-to-pay threshold.
Discussion
This study assessed the cost-effectiveness of two adaptations of the Look AHEAD ILI in an US military setting. Several of the findings are notable and worth further discussion. CI participants accumulated higher average costs but achieved better outcomes compared to SP participants which may help reduce discharges in the military, saving the cost of recruitment and training. The observed reduction in waist circumference is particularly notable because waist circumference has been described as an important predictor of obesity-related health risks, including risk of diabetes, coronary heart disease, and stroke.(23) Reduction in waist circumference is also of particular relevance to the Air Force military branch since abdominal circumference is currently included in their fitness assessment.(24) The CI intervention could be cost-saving, depending on the number of discharges prevented on account of the intervention. If implemented among 1,000 eligible personnel (e.g. BMI ≥ 25) and assuming recruitment and training costs of $75,000 per individual (10) and intervention costs of approximately $1,081 per participant, the CI intervention would save costs if at least 15 discharges would be prevented ([1,000 × $1,081]/ $75,000 = 14.4).
Although significantly better clinical outcomes among CI participants relative to SP at 12 months did not translate into significantly more QALYs at 12 months, a significant impact on QALYs was unlikely over such a short time horizon. Ackermann et al.(25) assessed the impact of weight changes on health-related quality of life in the Diabetes Prevention Program (DPP) and found that weight-related changes in quality of life scores were very small after one year (0.007 increase for every 5 kg weight loss).
Depending on the willingness-to-pay, the CI intervention could be deemed cost-effective. In our base-case cost-effectiveness analysis of the CI relative to the SP condition, ICERs for clinical outcome measures were $533.31 per kg lost and $698.77 per cm reduction in waist circumference. Thus, if the decision maker is willing to pay at least $533.31 per additional kg weight loss or $698.77 per additional cm reduction in waist circumference, CI would be considered cost-effective relative to SP. In the past, the figure of a lifetime cost of $50,000 per QALY has been used as society’s threshold to determine the cost-effectiveness of a given healthcare intervention. However, in recent years there has been a call for a much higher willingness-to-pay threshold and $100,000 and even $150,000 per QALY are being used.(26) It is important to note, however, that in our main analysis we estimate costs per QALY over one year for a health system and are unable to provide data from a societal perspective. It is arguable that the appropriate threshold for cost-effectiveness is lower from a system perspective than a societal perspective because the system perspective does not consider indirect costs, which are estimated to account for 54–59% of total costs of overweight and obesity.(27) If the system perspective benchmark is 54–59% of the societal benchmark (i.e. $54,000–88,500 per QALY), the CI intervention could still be considered cost-effective because the ICER in our base-case analysis of $61,268 per additional QALY for CI relative to SP does not exceed the upper value.
A meta- and cost-effectiveness analysis of commercial weight loss interventions reported an ICER of $155 (2013 US dollars) per kg of weight loss for Weight Watchers compared to a low-cost control intervention.(28) While this suggests that Weight Watchers is more cost-effective than the CI adaptation, it is unclear how effective an untailored commercial weight loss intervention would be in a military population. For example, the participants in the Fit Blue trial were considerably younger (mean 35 years old), face severe occupational consequences related to their weight and physical fitness, and bear significant stress related to potential deployments. In addition, active-duty personnel are unable to participate in in-person or group-based interventions due to Temporary Duty and changing schedules that are beyond their control. Military-specific characteristics and challenges that may influence the weight loss intervention success in this setting have been described elsewhere. (13, 14)
We examined two adaptations of the Look AHEAD intervention tailored to a military setting. The Look AHEAD ILI was modeled after the DPP, but included several modifications, such as more ambitious nutritional targets, and produced superior weight loss after one year.(29) Despite differences, the Look AHEAD ILI also shares many features with DPP including intervention sessions focusing on similar topics and the inclusion of toolbox strategies.(29) Several adaptations of the DPP and Look AHEAD interventions have been successfully translated into different settings(30–34), but only a few studies have included economic evaluations(32–34). The DPP has been reported as cost-effective relative to a placebo intervention among adults with impaired glucose tolerance.(35, 36) Costs of the more recent Look AHEAD clinical trial have been reported; however, to date, cost-effectiveness analysis has not yet been conducted.(37)
The present study is unique because it presents an economic evaluation of a weight loss intervention in the US military setting. There have been few randomized controlled trials of behavioral weight loss or weight management interventions in the US military setting, and economic evaluations have not been conducted alongside these trials.(38–40) To our knowledge, the present study is the first to conduct a cost-effectiveness analysis of a weight loss intervention in the US military setting.
Our study results should be interpreted with caution. While the base-case ICERs suggest that CI could be considered cost-effective, the computed ICERs were sensitive to interventionist wages. Further, probabilistic sensitivity analysis identified uncertainty around our cost-effectiveness estimates. QALYs have become the preferred method to assess the value of interventions or treatments in cost-effectiveness analysis. Nevertheless, the use of QALYs has also been criticized because the thresholds used to infer cost-effectiveness are arbitrary and the methodology used to estimate QALYs are usually based on subjects’ responses to a questionnaire; therefore representing their perceived value of their health status.(16, 41) In addition, a one-year time horizon, as was utilized in our analysis, may not be adequate to detect changes in QALYs because weight loss may not translate to improvements in quality of life over such a short time-horizon. We further conducted analyses with clinical outcome measures (weight loss and waist circumference reduction) that may be of interest to a decision maker. Reduction in waist circumference, for example, is relevant to the Air Force since this measure is part of their current fitness assessment. Without established benchmarks, however, these data do not allow for objective assessments of cost-effectiveness.
Like many behavioral intervention trials, missing follow-up information was a concern. Conservative approaches were implemented to minimize impact on our analyses. Our study time horizon (12 months) was relatively short, limiting our ability to track longer-term health outcomes. However, 12-month follow-up is common for the weight-loss and weight management interventions.(42, 43) The measure of meal replacements likely contains errors because the entry in the food log did not specify whether a meal consumed was a meal replacement. In addition, participants may have consumed but not self-monitored the meal. We conducted sensitivity analyses capturing this possible imprecision of the meal replacement estimate.
Since the Fit Blue trial did not include a no-intervention control group, it is unclear how the CI intervention may have performed relative to a true control population over the 12-month study period. A previous study suggests that Air Force service members not receiving any intervention gain weight over a one-year period(39); thus, the comparison to the SP intervention may be more conservative than a comparison to a no-intervention control group. Finally, the Fit Blue intervention was implemented in an Air Force setting; our study results may not be generalizable to other military branches or the general population.
Conclusion
After one year, the CI adaptation of the Look AHEAD Intensive Lifestyle Intervention was cost-effective relative to the SP adaptation at a willingness-to-pay of $100,000 per QALY. While ICERs for clinical outcome measures were calculated, established cost-effectiveness thresholds do not exist for these metrics. Our analyses indicate that based on these metrics the CI intervention could be deemed cost-effective across a wide range of willingness-to-pay thresholds. Future studies with a larger sample size, a longer follow-up period, and non-intervention control group are needed to address limitations of the current analysis.
Supplementary Material
Study Importance Questions.
What is already known about this subject?
Excess weight and inadequate fitness are prevalent problems among US military personnel and associated with adverse consequences on a societal and individual level.
Few studies examined weight loss interventions in a military setting and economic evaluations have not been conducted alongside these studies.
What does this study add?
This study is the first to conduct a cost-effectiveness analysis of a weight loss intervention in the US military setting and found that the Fit Blue intervention, an adaptation of the Look AHEAD Intensive Lifestyle Intervention, may offer a cost-effective approach to combating overweight in the US military.
Acknowledgements
We would like to thank the participants and the research team for their dedication to the research and the Look AHEAD study team for sharing the intervention materials. The individual participant data collected during the trial are available, after de-identification (upon request to the corresponding author).
Funding:
The study was funded by the National Institute of Diabetes and Digestive and Kidney Diseases (RO1 DK097158) of the National Institutes of Health, with the title of “Dissemination of the Look Ahead Weight Management Treatment in the Military,” Robert C. Klesges and Rebecca A. Krukowski, Principal Investigators.
Disclosure:
The authors declared no conflict of interest. The research represents a Collaborative Research and Development Agreement with the United States Air Force (CRADA #13–168-SG-C13001). The opinions expressed in this document are solely those of the authors and do not represent an endorsement by or the views of the United States Air Force, the Department of Defense, or the United States Government. The voluntary, fully informed consent of the subjects used in this research was obtained as required by 32 CFR 219 and DODI 3216.02_AFI 40–402. We gratefully acknowledge the donation of some of the meal replacements and snacks from ConAgra Foods, Inc. and the partnership with the Lose It!TM app and website and BodyTraceTM.
Footnotes
Clinical trial registration: The trial is registered on clinicaltrials.gov ().
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