Table 2.
Baseline association between the genetic risk score and CAD risk factors
| CRF | PRS | ||
|---|---|---|---|
| β | 95% CI | P | |
| BMI, kg/m2 | −0.029 | −0.319, 0.261 | 0.845 |
| Waist circumference, cm | 0.071 | −0.583, 0.724 | 0.832 |
| Fasting glucose, mmol/L | 0.007 | 0.014, 0.028 | 0.507 |
| LDLc, mmol/L | 0.094 | 0.055, 0.133 | <0.001 |
| HDLc, mmol/L# | 0.991 | 0.980, 1.001 | 0.090 |
| TG, mmol/L# | 1.017 | 0.994, 1.041 | 0.157 |
| SBP, mmHg | 0.544 | −0.107, 1.197 | 0.102 |
| DBP, mmHg | 0.524 | 0.094, 0.953 | 0.017 |
| CRP, mg/dL# | 1.029 | 0.982, 1.077 | 0.230 |
| tPA, ng/mL# | 0.996 | 0.980, 1.014 | 0.694 |
| Fibrinogen, μmol/L | 0.039 | −0.077, 0.154 | 0.511 |
Each CRF represents a separate general linear model on the association between baseline risk factor levels and the increment of 10 risk alleles in the PRS. P value derived by general linear model adjusted for age at randomization, sex, and PCs ancestry markers.
#
Regression coefficients for natural log–transformed CRFs are expressed as exp(β) differences in baseline risk factor levels.