Figure 2.

GluD1 Regulates Inhibitory Synaptic Transmission

(A) Schematic: recording of electroporated layer 2/3 CPN expressing shGluD1 with tdTomato (red) and neighboring control neuron (black) from juvenile mouse brain slice.

(B) Representative traces of mEPSCs and mIPSCs in control and shGluD1-electroporated neurons.

(C and D) Quantification of mEPSC amplitude (C) and frequency (D). Boxplots (left) show the distribution of the mean value per cell. n = 14 in both conditions. Cumulative distributions (right) of the amplitudes and interevent intervals of the first 200 events of each cell.

(E and F) Same as (C) and (D) for mIPSCs. n = 15 in both conditions.

Statistics: ns p > 0.05, ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, Mann-Whitney test.