Corrigendum to “Neoadjuvant 5-FU or Capecitabine Plus Radiation With or Without Oxaliplatin in Rectal Cancer Patients: A Phase III Randomized Clinical Trial” by Carmen J. Allegra et al. JNCI: J Natl Cancer Inst. 2015; 107(11): doi: 10.1093/jnci/djv248.
On page 4, the sentence “Further unplanned analysis that included only patients at high risk for recurrence (lymph node-positive and clinical stage TIII/IV disease) also demonstrated …” should instead read as the following: “Further unplanned analysis that included only patients at high risk for recurrence (pathologic lymph node-positive and pathologic stage TIII/IV disease) also demonstrated …”
On page 5, the sentence “Although there were numerically more deaths (on treatment and within 45 days of completing neoadjuvant treatment) in the capecitabine arms (4 and 5 vs 1 each for the capecitabine vs 5-FU arms, respectively), these differences did not reach statistical significance (p=0.64 Fisher’s exact test, post-amendment, 2 vs 9 deaths (0.091, pre and post-amendment, 3 vs 10 deaths)” should instead read as the following: “There were numerically more deaths (on treatment and within 45 days of completing neoadjuvant treatment) in the capecitabine arms (4 and 5 vs 1 each for the capecitabine vs 5-FU arms, respectively), and these differences did reach statistical significance (p=0.037 Fisher’s exact test, post-amendment, 2 vs 9 deaths (0.056, pre and post-amendment, 3 vs 10 deaths).”
On page 6, the sentence “Although we did observe a numerically greater number of deaths while on or within 45 days of active treatment … this increase did not reach statistical significance and the overall survival among the arms was identical HR = 1.0)” should instead read as the following: “We observed a numerically greater number of deaths while on or within 45 days of active treatment … and this increase did reach statistical significance but the overall survival among the arms was identical (HR = 0.94).”
On page 7 in the discussion, the sentence “An unplanned retrospective exploratory analysis of only those patients with either clinical stage TIII with node positivity or those with T4 lesions showed …” should instead read as the following: “An unplanned retrospective exploratory analysis of only those patients with either pathologic stage TIII/IV with node positivity showed …”
In addition, we have published a new Figure 5, which contains the corrected hazard ratios in both panel A and B that match the original text. The hazard ratios were reversed in the original figure, but the text in the results was correct.
The authors regret the errors.