Table 1:

Summary of Cancer-on-Chip Studies

No.	Cancer type	Method	Result	Authors	Year	Ref.
1.	Breast cancer	Microfluidic 3D in vitro model for breast cancer metastasis to bone	3D in vitro data on extravasation and micrometastasis generation of breast cancer cells within bone microenvironment	Bersini et al.	2014	(51)
2.	Breast cancer	3D bone-on-chip for bone metastasis study of breast cancer cells	Unique hallmarks of breast cancer bone in colonization observed, previously only seen in vivo	Hao et al.	2018	(50)
3.	Breast cancer	Disease-on-a-chip model in which cancer grows within phenotypically normal breast luminal epithelium on semicircular acrylic supports	Mimicry of tumor environment provides a framework for the design and test of anti-cancer therapies	Vidi et al.	2014	(54)
4.	Breast cancer	3D high-throughput microfluidic platform for screening of three triple negative breast cancer lines against several anti-cancer drugs	High-throughput organ on a chip platform to select therapies in personalized medicine	Lanz et al.	2017	(12)
5.	Cancer immune interactions	Organ-on-chip tool to evaluate cancer-immune cell interactions	Quantitative confirmation of the essential role of FPR1 in cancer chemotherapy response	Biselli et al.	2017	(60)
6.	Lung cancer	Multi-organ microfluidic chip mimicking in vivo microenvironment of lung cancer metastasis	Multi-organ system provides useful tool to investigate cell-cell interactions in metastasis	Xu et al.	2016	(53)
7.	Lung	Organ-on-chip model recapitulates orthotopic lung cancer growth and therapeutic response	Discovery of mechanical stimuli dependent TKI therapy resistance	Hassell et al.	2017	(52)
8.	Pancreatic ductal adenocarcinoma	Microfluidic 3D platform for culturing pancreatic ductal adenocarcinoma cells	Growth characteristics closer to those of cells grown as spheroids than as classical 2 dimensional (2D) in vitro cultures.	Beer et al.	2017	(13)