Table 1.
Baseline characteristics of study participants
| Total study population n=204 (%) |
Hospital-based management n=101 (%) |
Home-based management n=103 (%) |
|
| Patient characteristics | |||
| Patient age (median, IQR) | 36.5 (30.0–44.0) | 37.0 (30.0–44.0) | 36.0 (30.0–43.0) |
| Patient sex (% male) | 142 (69.6) | 77 (74.8) | 65 (64.4) |
| TB class | |||
| Pulmonary | 182 (89.2) | 84 (83.2) | 98 (95.2) |
| Extrapulmonary | 22 (10.78) | 17 (16.8) | 5 (4.8) |
| TB category* | |||
| Relapse | 99 (48.5) | 44 (43.6) | 55 (53.4) |
| TALTFU | 5 (2.5) | 2 (2.0) | 3 (2.9) |
| Fail | 15 (7.4) | 5 (5.0) | 10 (9.7) |
| Other | 85 (41.7) | 50 (49.5) | 35 (34.0) |
| Sputum culture positive | 80 (39.2) | 38 (37.6) | 42 (40.8) |
| HIV positive | 164 (80.4) | 87 (86.1) | 77 (74.8) |
| Established on ART if HIV positive | 131 (80.9) | 70 (81.4) | 61 (80.26) |
| CD4 count (cells/mm3; median, IQR) | 177 (82–423) | 161 (68–339) | 225 (117–560) |
| No of previous TB episodes | |||
| 1 | 174 (85.3) | 88 (87.1) | 86 (83.5) |
| 2 | 28 (13.7) | 12 (11.9) | 16 (15.5) |
| >2 | 2 (1.0) | 1 (1.0) | 1 (1.0) |
| Baseline Karnofsky Score (median, IQR) | 90 (80–100) | 90 (80–90) | 90 (90–100) |
| History of alcohol excess† | 47 (23.7) | 21 (21.1) | 26 (26.3) |
| Guardian characteristics | |||
| Guardian age (median, IQR) | 32 (26–40) | 33 (28–39) | 30 (25–40) |
| Guardian sex (% male) | 62 (30.4) | 28 (27.7) | 34 (33.0) |
| Guardian level of education | |||
| None | 4 (2.0) | 4 (4.0) | 0 (0.0) |
| Standard 1–4 | 33 (16.2) | 20 (19.8) | 13 (12.6) |
| Standard 5–8 | 52 (25.5) | 26 (25.7) | 26 (25.2) |
| Form 1–2 | 42 (20.6) | 18 (17.8) | 24 (23.3) |
| Form 3–4 | 45 (22.1) | 20 (19.8) | 25 (24.3) |
| University | 28 (13.7) | 13 (12.9) | 15 (14.6) |
| Guardian relationship to patient | |||
| Spouse | 74 (36.3) | 37 (36.6) | 37 (35.9) |
| Sibling | 56 (27.5) | 28 (27.7) | 28 (27.2) |
| Parent | 16 (7.8) | 9 (2.9) | 7 (6.8) |
| Child | 19 (9.3) | 7 (6.9) | 12 (11.7) |
| Aunt/uncle | 14 (6.9) | 7 (6.9) | 7 (6.8) |
| Niece/nephew | 9 (4.4) | 3 (3.0) | 6 (5.8) |
| Friend/neighbour | 16 (7.8) | 10 (9.9) | 6 (5.8) |
*Standard WHO definitions of TB category: relapse=a patient previously treated for TB, declared cured or treatment completed, who is diagnosed again with smear or culture-positive TB; treatment after failure=a patient who is started on retreatment regimen after having failed previous treatment; treatment after loss to follow-up (TALTFU)=a patient who returns to treatment, positive bacteriologically, following interruption of treatment for 2 or more consecutive months; other previously treated=all previously treated cases that do not fit any of the above definitions http://www.who.int/tb/err/rr_final_forms_en.pdf.
†As defined by the Alcohol Use Disorders Identification Test.36