Table 3.
Aqueous solubility results of EM-PVP-K30 solid dispersions prepared using varied feed ratios. Note: Different lower-case letters (such as a, b, c, d, e, f, g, and h) in the same column indicate significant differences in the aqueous solubility of different samples (Duncan’s tests, p ≤ 0.05).
| Samples | Aqueous Solubility (×10−3 mg/mL) | Times of Solubility Improvement |
|---|---|---|
| EM technical | 23.36 ± 0.33a | - |
| 1:1 feed ratio EM-PVP-K30 solid dispersions | 81.76 ± 0.95b | 3.5 |
| 1:2 feed ratio EM-PVP-K30 solid dispersions | 167.38 ± 2.16e | 7.2 |
| 1:4 feed ratio EM-PVP-K30 solid dispersions | 238.43 ± 1.04g | 10.2 |
| 1:10 feed ratio EM-PVP-K30 solid dispersions | 876.22 ± 4.27h | 37.5 |
| 1:50 feed ratio EM-PVP-K30 solid dispersions | 223.95 ± 2.59f | 9.6 |
| 1:100 feed ratio EM-PVP-K30 solid dispersions | 117.48 ± 1.26d | 5.0 |
| 1:10 feed ratio physical mixture of EM and PVP-K30 | 99.79 ± 4.15c | 4.3 |