Fig. 3.

AUC values and their standard errors for PRS of schizophrenia for genotyped SNPs in the MGS study. PRSs were trained based on the PGC summary data excluding the MGS study; the MGS study was used as the validation data for calculating AUC and its variance. Analysis was restricted to SNPs genotyped in MGS. The x-coordinate is the P-value threshold (for training dataset) for including SNPs in PRS. AUC₀ and SE₀ were calculated using individual level data. AUC₁ and SE₁ were calculated using SummaryAUC based on GWAS summary data in MGS. $r^2=0.01$: SNPs were LD-clumped using $r^2=0.01$ in PLINK. $r^2=0.2$: SNPs were LD-clumped using $r^2=0.2$ in PLINK