Fig. 4.

AUC values and their standard errors for PRS of schizophrenia for genotyped SNPs in validation dataset. PRSs were trained based on the PGC data excluding the MGS study; the MGS study was used as the validation data for calculating AUC and its variance. The x-coordinate is the number of SNPs (with smallest P-values in the training dataset) for PRS. AUC₀ and SE₀ were calculated assuming individual level data. AUC₁ and SE₁ were calculated using SummaryAUC based on GWAS summary data in MGS. $r^2=0.01$: SNPs were LD-clumped using $r^2=0.01$ in PLINK. $r^2=0.2$: SNPs were LD-clumped using $r^2=0.2$ in PLINK