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. 2019 Dec 11;8:e49630. doi: 10.7554/eLife.49630

Figure 5. Heatmap visualisations of k-mean group membership across experiments.

The percentage of group representation per strain is shown by the cell color. Cell color closer to red indicates a higher representation of mice in the k-mean grouping. Mice are divided by sex (male and female), genotype (W for wild type and T for transgenic), and age (3–6, 7–10, and 11–13). Analysis of the PAL (A) task data uncovered early group membership variability in the APP/PS1 mouse line, as well as later group membership differences in the male 5xFAD mice. In the PD (B) experiment, only APP/PS1 transgenic mice showed an increase in membership of the low performing group compared to wildtype. See also S5. In the 5-CSRTT (C), transgenic 3xTG-AD and 5xFAD mice were found to shift to the lowest performing group of mice.

Figure 5.

Figure 5—figure supplement 1. Results of longitudinal clustering analysis of PAL, PD and 5-CSRTT data. z-scores for parameters assessed during the 5-CSRTT, sorted by cluster.

Figure 5—figure supplement 1.

For PAL – (A) Accuracy across blocks by cluster. (B) Number of correction trials across blocks by cluster. (C) Correct Touch latency across blocks by cluster (D) Reward latency across blocks by cluster. (E) Number of mice belonging to each cluster across strain, age, sex and genotype. The high performing cluster is characterised by low errors and high accuracy. The middle performing cluster is characterised by middle accuracy and errors, as well slow response times. The low performing cluster is characterized by low accuracy and high errors. For PD - (F) Response accuracy across trials by cluster. (G). Errors committed across trials by cluster. (H) Response latency across trials by cluster. (I) Reward collection latency across trials by cluster. The high performing cluster is characterised by low errors and high accuracy. The middle performing cluster is characterised by middle accuracy and errors, and slow response times. The low performing cluster is characterised by low accuracy and high errors. (J) Number of mice belonging to each cluster across strain, age, sex and genotype. For 5-CSRTT - (K) Response accuracy across trials as stimulus duration is reduced. (L) Omission errors committed as stimulus duration is reduced. (M) Perseverative responses as stimulus duration is reduced. (N) Premature responses as stimulus duration is reduced. (O) Correct response latency as stimulus duration is reduced. (P) Reward collection latency as stimulus duration is reduced. The high performing cluster is characterised by low omissions, high accuracy, but high number of perseverative responses. The middle performing cluster is characterised by middle accuracy and omission, and increased number of premature responses. The low performing cluster is characterised by low accuracy, high omission, and slow response times (Correct touch latency and reward collection latency) (Q) Number of mice belonging to each cluster across strain, age, sex and genotype.