In the above-named article by Mohler ER III, Ellenberg SS, Lewis CE, Wenger NK, Budoff MJ, Lewis MR, Barrett-Connor E, Swerdloff RS, Stephens-Shields A, Bhasin S, Cauley JA, Crandall JP, Cunningham GR, Ensrud KE, Gill TM, Matsumoto AM, Molitch ME, Pahor M, Preston PE, Hou X, Cifelli D, and Snyder PJ. (J Clin Endocrinol Metab. 2018;103(2):681–688; doi: 10.1210/jc.2017–02243), the following error occurred in Table 4: The mean and standard deviation of the baseline, month 3, and month 12 values of insulin in the placebo arm appear as 17.5 ± 12.2, 19.2 ± 14.8, and 19.3 ± 14.9, respectively; the correct values are 19.2 ± 14.8, 19.3 ± 14.9, and 18.5 ± 16.1. The corrected table is shown on the following page.
Table 4.
Markers of Glucose Metabolism
| Assay | Testosterone | Placebo | Difference in Change Over Timea (95% CI) | P Value | ||||
|---|---|---|---|---|---|---|---|---|
| Baseline (n) | Month 3 (n) | Month 12 (n) | Baseline (n) | Month 3 (n) | Month 12 (n) | |||
| Glucose, mg/dL | 114.4 ± 28.2 (369) | 113.6 ± 32.4 (367) | 115.7 ± 30.9 (346) | 116.0 ± 27.8 (369) | 116.1 ± 29.1 (367) | 118.2 ± 35.2 (333) | −1.5 (−4.3, 1.3) | 0.30 |
| Insulin, µU/mL | 19.6 ± 19.0 (367) | 17.3 ± 12.5 (365) | 17.9 ± 13.6 (342) | 19.2 ± 14.8 (364) | 19.3 ± 14.9 (365) | 18.5 ± 16.1 (330) | −1.7 (−3.1, −0.3) | 0.02 |
| HOMA-IRb | 5.8 ± 6.3 (367) | 5.1 ± 4.6 (365) | 5.5 ± 6.4 (342) | 5.8 ± 6.0 (364) | 5.9 ± 6.2 (365) | 5.6 ± 5.5 (330) | −0.6 (−1.2, −0.1) | 0.03 |
| HbA1c,c% | 6.3 ± 0.8 (249) | — | 6.3 ± 0.9 (250) | 6.3 ± 0.8 (243) | — | 6.4 ± 1.0 (242) | −0.07 (−0.2, 0.01) | 0.09 |
Values are means ± standard deviation and (number of participants).
Abbreviations: CI, confidence interval; HOMA-IR, homeostatic model assessment of insulin resistance.
aAverage over all observations, adjusting for balancing factors and baseline value. Positive values mean men in the testosterone arm increased more or decreased less than men in the placebo arm; negative values mean men in the placebo arm increased more or decreased less than men in the testosterone arm.
bHOMA-IR calculated as glucose × insulin/22.5.
cCollection of blood for HbA1c did not begin until after the trial was under way, so the n is smaller for this parameter.