CORRIGENDUM FOR “Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society* Clinical Practice Guideline”

In the above-named article by Speiser PW, Arlt W, Auchus RJ, Baskin LS, Conway GS, Merke DP, Meyer-Bahlburg HFL, Miller WL, Murad MH, Oberfield SE, and White PC (J Clin Endocrinol Metab. 2018;103(11):4043–4088; doi: 10.1210/jc.2018-01865), the following errors occurred.

In the Summary of Recommendations, Section: Treatment of classic congenital adrenal hyperplasia, Recommendation 4.3 on page 4044, and Section 4. Treatment of Classic CAH, Recommendation 4.3 on page 4056, the Recommendation was originally:

4.3 In the newborn and in early infancy, we recommend using fludrocortisone and sodium chloride supplements to the treatment regimen. (1|⊕⊕⊕○)

The Recommendation should read:

4.3 In the newborn and in early infancy, we recommend adding fludrocortisone and sodium chloride supplements to the treatment regimen. (1|⊕⊕⊕○)

In the Summary of Recommendations, Section: Treatment of classic congenital adrenal hyperplasia, Subsection: Monitoring therapy, Recommendation 4.14 on page 4045, and Section: Treatment of classic congenital adrenal hyperplasia, Subsection: Monitoring therapy, Recommendation 4.14 on page 4059, the Recommendation was originally:

4.14 In pediatric patients with CAH under the age of 2 years, we advise annual bone age assessment until near-adult height is attained. (Ungraded Good Practice Statement)

The Recommendation should read:

4.14 In pediatric patients with CAH over the age of 2 years, we advise annual bone age assessment until near-adult height is attained. (Ungraded Good Practice Statement)

In the Reference List on page 4076, Reference 30 was originally:

30. Speiser PW, Dupont BO, Rubinstein P, Piazza A, Kastelan A, New MI. High frequency of nonclassical steroid 21-hydroxylase deficiency. Obstet Gynecol Surv. 1986;41(4):244–245.

The Reference should read:

30. Speiser PW, Dupont BO, Rubinstein P, Piazza A, Kastelan A, New MI. High frequency of nonclassical steroid 21-hydroxylase deficiency. Am J Hum Genet. 1986;41(4):244–245.

In the Reference List on page 4087, Reference 379 was originally:

379. Clayton PE, Miller WL, Oberfield SE, Ritzén EM, Sippell WG, Speiser; ESPE/LWPES CAH Working Group. Consensus statement on 21-hydroxylase deficiency from the European Society for Pediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society. Horm Res. 2002;58(4):188–195.

It should read as:

379. Clayton PE, Miller WL, Oberfield SE, Ritzén EM, Sippell WG, SpeiserPW; ESPE/LWPES CAH Working Group. Consensus statement on 21-hydroxylase deficiency from the European Society for Pediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society. Horm Res. 2002;58(4):188–195.

On page 4061, Table 5 was originally:

Table 5.

Utility of Various Analytes for Monitoring CAH Treatment

Patients	Analyte	Physiology	Goals and Comments
All ages	Plasma renin	Volume status	Low to normal unless hypertensive
	Potassium	MC replacement	Goal is normal
	Sodium	GC and MC replacement	Goal is normal
	Testosterone	Total androgens	Goal is at or near normal
	Androstenedione	Mostly adrenal origin	Goal is at or near normal
	Sex hormone–binding globulin	Testosterone-binding protein	For calculation of free and bioavailable testosterone
	17OHP	Variable	Normal values indicate overtreatment
Men	Testosterone	Adrenal or gonadal origin	Interpret abnormal values in context of gonadotropins and androstenedione levels
	Gonadotropins	Gonadal axis status	Low indicates poor control
	Androstenedione	Mainly adrenal	Goal is <0.5× testosterone
	Semen analysis	Fertility	Goal is normal
Women	Follicular-phase progesterone	Mainly adrenal origin when elevated	Goal is <0.6 ng/mL (<2 nmol/L) for women trying to conceive

Table 5 should read as:

Table 5.

Utility of Various Analytes for Monitoring CAH Treatment

Patients	Analyte	Physiology	Goals and Comments
All ages	Plasma renin	Volume status	Low to normal unless hypertensive
	Potassium	MC replacement	Goal is normal
	Sodium	GC and MC replacement	Goal is normal
	Testosterone	Total androgens	Goal is at or near normal
	Androstenedione	Mostly adrenal origin	Goal is at or near normal
	Sex hormone–binding globulin	Testosterone-binding protein	For calculation of free and bioavailable testosterone
	17OHP	Adrenal or ovarian origin	Normal values indicate overtreatment
Men	Testosterone	Adrenal or gonadal origin	Interpret abnormal values in context of gonadotropins and androstenedione levels
	Gonadotropins	Gonadal axis status	Low indicates poor control
	Androstenedione	Mainly adrenal	Goal is <0.5× testosterone
	Semen analysis	Fertility	Goal is normal
Women	Follicular-phase progesterone	Mainly adrenal origin when elevated	Goal is <0.6 ng/mL (<2 nmol/L) for women trying to conceive